Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition [PDF]
, 2016 Perforin, a pore-forming toxin released from secretory granules of NK cells and CTLs, is essential for their cytotoxic activity against infected or cancerous target cells.
Chaudhry, MS +7 more
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Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]
, 2020 In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena +3 more
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Secondary Primary Malignancies in Multiple Myeloma: An Old Nemesis Revisited
Advances in Hematology, 2012 The treatment of myeloma has undergone extraordinary improvements in the past half century. These advances have been accompanied by a concern for secondary primary malignancies (SPMs).
Jay Yang +2 more
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Case Reports in Medicine, 2015 In rare instances, patients may be diagnosed with two different primary malignancies. Though such synchronous malignancies have been documented in sporadic case reports, the overwhelming majority of malignancies involving multiple organs can be ...
Deepu Daniel, Leah Delumpa, Natasha Bray
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Multiple synchronous primary malignancies induced by benzene exposure: a case report
Journal of Occupational Medicine and Toxicology, 2009 Background Chronic exposure to high concentrations of benzene is usually associated with the development of haematological diseases. However, solid tumors induced by benzene exposure are less frequent.
Shen Huahao, Zhang Gensheng, Wang Pingli
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Primary dermal melanoma in a patient with a history of multiple malignancies: a case report with molecular characterization [PDF]
, 2013 Introduction: Primary dermal melanoma (PDM) is a recently described clinical entity accounting for less than 1% of all melanomas. Histologically, it is located in the dermis or subcutaneous tissue, and it shows no connections with the overlying epidermis.
Colombino, Maria +9 more
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Frontiers in OncologyRationaleAlthough the incidence of multiple primary malignancies (MPM) is increasing, triple primary malignancies (TPM) remain extremely rare. The pathogenesis of MPM is currently unclear, and there is a lack of optimal management strategies.
Xiangxue Li +9 more
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Metachronous malignancies in head and neck region: Report of two cases
Indian Journal of Pathology and Microbiology, 2014 The development of a second primary cancer after treatment of the first with radiotherapy or chemotherapy is well documented. Multiple metachronous primary cancers are known to occur in an individual, but it is often seen with hematological malignancies ...
Sushma Yalavarthi +3 more
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Eccrine porocarcinoma of the head: An important differential diagnosis in the elderly patient [PDF]
, 2008 Background: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations. Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in ...
Akiyoshi E +25 more
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Diagnosis of cutaneous T-cell lymphoma by insurance type before and after the Affordable Care Act: a national database study [PDF]
, 2019 The Affordable Care Act (ACT) was implemented to increase health care access and reduce the uninsured in the age group between pediatric and Medicare populations (18-64). The association of the ACA with insurance type upon diagnosis (uninsured, Medicaid,
Duvic, Madeleine +3 more
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