Results 61 to 70 of about 1,293,842 (319)

Multiple Primary Malignant Neoplasms in an Elderly Patient

Cureus, 2018
Only a few case reports to date have described patients with three or more cancers. However, the incidence of multiple primary malignancies is increasing due to the improved survival of cancer patients, the prolonged lifespan of the general population ...
Jai D Parekh, S. Kukrety, A. Thandra, Carrie Valenta   +3 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Current knowledge and future research directions in treatment-related second primary malignancies

EJC Supplements, 2014
Currently, 17–19% of all new primary malignancies occur in survivors of cancer, causing substantial morbidity and mortality. Research has shown that cancer treatments are important contributors to second malignant neoplasm (SMN) risk.
Lindsay M. Morton, Anthony J. Swerdlow, Michael Schaapveld, Safaa Ramadan, David C. Hodgson, John Radford, Flora E. van Leeuwen   +6 more
doaj   +1 more source

[Multiple primary neoplasms].

Wiadomosci lekarskie (Warsaw, Poland : 1960), 1990
In the years 1980-1987 in the Department of Internal Diseases, Silesian Medical Academy in Katowice 32 patients were observed with multiple malignant neoplasms of various organs. The time from the diagnosis of the first neoplasm to the appearance of the second one was from 0 to 168 months (mean 61.8 months).
W, Poborski, M, Machalski, A, Tomiczek, A, Kozaczka   +3 more
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Metachronous Primary Cerebral Rhabdomyosarcoma After Treatment of Oral Primitive Neuroectodermal Tumor/ Ewing’s Sarcoma in a School-Aged Girl

Philippine Journal of Pathology, 2020
Multiple primary malignancies are defined as two or three malignant neoplasms arising in different organ systems. Several cases of multiple primary malignancies are emerging in recent years due to the advancement in medical therapy and diagnostics ...
Danielle Anne Gonong, Manuelito Madrid
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

[Multiple primary malignant neoplasms detected by PET/CT in cancer patients].

Revista médica de Chile (Impresa), 2017
Background: Imaging with F18-fluorodeoxyglucose PET/CT is used to determine sites of abnormal glucose metabolism and can be used to characterize and localize many types of tumors.
D. Ladrón de Guevara, R. Quera, Sebastián Rozas, Shmuel Schacher, J. M. Reyes, Claudio Pardo, Raúl Pefaur   +6 more
semanticscholar   +1 more source