Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity [PDF]
arXiv, 2023 In some patients of myeloproliferative neoplasm, two genetic mutations can be found: JAK2 V617F and TET2. When one mutation is present or not, the other mutation has different effects on regulating gene expressions. Besides, when both mutations are present, the order of occurrence might make a difference.
arxiv
Pancreatic cysts suspected to be branch duct intraductal papillary mucinous neoplasm without concerning features have low risk for development of pancreatic cancer. [PDF]
, 2015 BackgroundThe risk of developing pancreatic cancer is uncertain in patients with clinically suspected branch duct intraductal papillary mucinous neoplasm (BD-IPMN) based on the "high-risk stigmata" or "worrisome features" criteria proposed in the 2012 ...
Fehmi, Syed A +9 more
core +1 more source
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm [PDF]
arXiv, 2023 We develop a modeling framework for cancer progression that distinguishes the order of two possible mutations. Recent observations and information on myeloproliferative neoplasms are analyzed within our framework. In some patients with myeloproliferative neoplasms, two genetic mutations can be found, JAK2 V617F and TET2.
arxiv
FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source
Polyneoplasia associated with gastrointestinal stromal tumor: literature review and case report
Сибирский онкологический журнал, 2020 The purpose of the study was to demonstrate a rare clinical case of polyneoplasia associated with GIST, combining three malignant neoplasms of different nosological affiliation and different tissue origin.
N. V. Vasilyev +6 more
doaj +1 more source
Banana for scale: Gauging trends in academic interest by normalising publication rates to common and innocuous keywords [PDF]
arXiv, 2021 Many academics use yearly publication numbers to quantify academic interest for their research topic. While such visualisations are ubiquitous in grant applications, manuscript introductions, and review articles, they fail to account for the rapid growth in scientific publications.
arxiv
Clonal Composition of Human Adrenocortical Neoplasms [PDF]
, 1994 The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S. +7 more
core
Liver Resection for Primary Hepatic Neoplasms. [PDF]
, 1988 Subtotal hepatic resection was performed in 356 patients; 87 had primary hepatic malignancies, 108 had metastatic tumors, and 161 had benign lesions including 8 traumatic injuries. The global mortality was 4.2%.
C. Couinaud +16 more
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source