Results 141 to 150 of about 56,538 (251)
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
Bithalamic Inflammation in Relapsing-Remitting Multiple Sclerosis [PDF]
The Neurohospitalist, 2017 Andrew R, Romeo, Maulik, Shah
openaire +2 more sources
Blood–Brain Barrier: Structure, Function, Diseases, and Drug Delivery Systems
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract illustrates how blood–brain barrier‐targeted nanomedicine integrates diverse nanocarrier platforms with mechanism‐based therapeutic strategies to overcome delivery barriers in ischemic stroke, enabling targeted modulation of oxidative stress, inflammation, excitotoxicity, and neuronal survival.
Yanan He +10 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2017 Background: The aim of this study was to determine the efficacy of monthly cyclophosphamide and daily fingolimod in treatment of patients with multiple sclerosis (MS) and to compare these two treatment strategies.
Vahid Shaygannezhad, Hassan Amini
doaj
Natural Sciences, Volume 6, Issue 2, April 2026.Dental pulp stem cellderived exosomes and folic acid are evaluated for their effects on gene expression in an in‐vitro periodontal injury model. Human gingival fibroblasts subjected to oxidative and mechanical injury are treated with folic acid, exosomes, or their combination.
Saghar Zarei +4 more
wiley +1 more source
European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta +12 more
wiley +1 more source
Health Expectations, Volume 29, Issue 2, April 2026.ABSTRACT Introduction Nutrition is often overlooked in multiple sclerosis (MS) care, leading to a gap in comprehensive patient management. Developing MS‐specific nutrition educational resources could address this gap. This study therefore aimed to collaboratively develop MS‐specific nutrition educational resources with healthcare professionals (HCPs ...
Shoroog Allogmanny +3 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 4, April 2026.This prospective study addresses the need for efficient multiple sclerosis (MS) biomarkers by validating a biological diagnostic algorithm. Based on paired cerebrospinal fluid (CSF) and serum samples from derivation and validation cohorts, the algorithm integrates the kappa free light chain (KFLC) index and oligoclonal bands (OCBs).
Noé Verchere +9 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 4, April 2026.Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum +7 more
wiley +1 more source