Results 161 to 170 of about 4,730,461 (228)

Dissociating Fatigue and Fatigability in Multiple Sclerosis: The Role of Cognitive Processing Speed

open access: yesEuropean Journal of Neurology, Volume 33, Issue 10, October 2026.
In people with multiple sclerosis, task‐induced fatigability normalized once cognitive load was calibrated to each patient's processing speed, whereas perceived fatigue remained elevated. Long‐term fatigue—but not fatigability—was associated with putamen and callosal atrophy, an association mediated by slowed processing speed, which emerges as a key ...
Jeromy Hrabovecky   +8 more
wiley   +1 more source

Patterns and predictors of transition between multiple sclerosis phenotypes: A longitudinal analysis. [PDF]

open access: yesMult Scler J Exp Transl Clin
Bose G   +6 more
europepmc   +1 more source

Comparator Event Rates, Baseline Activity, and Operational Selection Pressure in Relapsing Multiple Sclerosis Trials: A Meta‐Epidemiological Analysis

open access: yesEuropean Journal of Neurology, Volume 33, Issue 10, October 2026.
Across 15 treated‐reference arms from nine phase 3 relapsing multiple sclerosis programs, reference‐arm relapse rates declined alongside baseline prior‐year relapse activity. A geography‐weighted Operational Selection Pressure Index, reflecting ocrelizumab approval maturity during recruitment, was associated with lower program‐level relapse rates but ...
Steffen Pfeuffer   +3 more
wiley   +1 more source

Advances in the treatment of systemic lupus erythematosus: Biologicals, small‐molecular agents, and cell‐depleting therapies coming to the clinic

open access: yesJournal of Internal Medicine, Volume 300, Issue 4, Page 461-479, October 2026.
Abstract Systemic lupus erythematosus (SLE; lupus) remains a particular challenge for the practicing clinician on account of its chronic undulating and unpredictable course, its diverse manifestations, and—until recently—limited treatment options all associated with considerable downsides.
Ronald van Vollenhoven
wiley   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

open access: yesAngewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber   +4 more
wiley   +1 more source

Cognition in multiple sclerosis within the modern diagnostic and treatment era. [PDF]

open access: yesBrain
Sumowski JF   +10 more
europepmc   +1 more source

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