Results 91 to 100 of about 752,420 (346)

The impact of social and environmental factors on triggering multiple sclerosis onset, before and during the COVID-19 pandemic: a retrospective study from Iran

BMC Neurology
Background Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. The first presentation’s possible triggers are still controversial among scientists. The objective of this study is to investigate and
Naghmeh Abbasi Kasbi, Fereshteh Ghadiri, Abdorreza Naser Moghadasi, Faezeh Khodaie, Kosar Kohandel, Nasim Rezaeimanesh, Maryam Karaminia, Mohammad Ali Sahraian   +7 more
doaj   +1 more source

Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study [PDF]

, 2018
Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains ...
Amann, M, Andelova, M, Barkhof, F, Burggraaff, J, Cawley, N, Ciccarelli, O, Collorone, S, Cortese, R, Gasperini, C, Hagens, MH, Killestein, J, Kilsdonk, ID, Lieb, JM, Lissenberg-Witte, BI, Lukas, C, MAGNIMS Study Group, Oreja-Guevara, C, Palace, J, Pantano, P, Rovira, A, Ruggieri, S, Sbardella, E, Wattjes, MP, Wuerfel, J   +23 more
core   +4 more sources

Performance of Composite Endpoints Defining Progression Independent of Relapse Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The characteristics and utility of composite progression independent of relapse activity (cPIRA; worsening on the Expanded Disability Status Scale [EDSS], or 9‐Hole Peg Test, or Timed 25‐Foot Walk Test) were evaluated as an endpoint in relapsing multiple sclerosis (RMS) trials using the ENSEMBLE (NCT03085810) and pooled OPERA I/II ...
Ludwig Kappos, Sean Yiu, Jason Reucassel, Jiwon Oh, Cristina Granziera, Joep Killestein, Robert A. Bermel, Claude Berge, Agne Kazlauskaite, Hans‐Martin Schneble, Frank Dahlke, Bruce A. C. Cree   +11 more
wiley   +1 more source

Functional connectivity changes and their relationship with clinical disability and white matter integrity in patients with relapsing-remitting multiple sclerosis [PDF]

, 2015
Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating the relationship of resting-state functional connectivity with microstructural brain damage, as assessed by diffusion tensor maging ...
Filippini, N, Pantano, Patrizia, Petsas, Nikolaos, Piattella, MARIA CRISTINA, Pozzilli, Carlo, Prosperini, Luca, Sbardella, Emilia, Tona, Francesca, Upadhyay, Neeraj   +8 more
core   +1 more source

Cervical Spinal Cord Magnetization Transfer Ratio and Its Relationship With Clinical Outcomes in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The cervical spinal cord (cSC) is highly relevant to clinical dysfunction in multiple sclerosis (MS) but remains understudied using quantitative magnetic resonance imaging (MRI). We assessed magnetization transfer ratio (MTR), a semi‐quantitative MRI measure sensitive to MS‐related tissue microstructural changes, in the cSC and its ...
Lisa Eunyoung Lee, Julien Cohen‐Adad, Irene M. Vavasour, Melanie Guenette, Katherine Sawicka, Neda Rashidi‐Ranjbar, Nathan Churchill, Akash Chopra, Adelia Adelia, Pierre‐Louis Benveniste, Anthony Traboulsee, Nathalie Arbour, Fabrizio Giuliani, Larry D. Lynd, Scott B. Patten, Alexandre Prat, Alice Schabas, Penelope Smyth, Roger Tam, Yunyan Zhang, Simon J. Graham, Mojgan Hodaie, Anthony Feinstein, Shannon Kolind, Tom A. Schweizer, Jiwon Oh, CanProCo Study Group   +26 more
wiley   +1 more source

Lifetime exposure to smoking and substance abuse may be associated with late-onset multiple sclerosis: a population-based case-control study

BMC Neurology
Background Late-onset multiple sclerosis (LOMS), defined as the development of MS after the age of 50, has shown a substantial surge in incidence rates and is associated with more rapid progression of disability.
Naghmeh Abbasi Kasbi, Sajjad Ghane Ezabadi, Kosar Kohandel, Faezeh Khodaie, Amir Hossein Sahraian, Sahar Nikkhah Bahrami, Mahsa Mohammadi, Amir Almasi-Hashiani, Sharareh Eskandarieh, Mohammad Ali Sahraian   +9 more
doaj   +1 more source

Glial Fibrillary Acidic Protein Astrocytopathy Based on a Two‐Center Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glial fibrillary acidic protein astrocytopathy (GFAP‐A) is a recently defined nosological form belonging to the class of autoimmune inflammatory disorders affecting the central nervous system (CNS). Here, we report the clinical and MRI characteristics, treatment, and prognosis of a GFAP‐A cohort from two centers in China.
Ti Wu, Hao Zhang, Chao Gao, Qiuhua Yu, Moli Fan, Lin‐Jie Zhang, Haipeng Zhang, Hengri Cong, Yuzhen Wei, Chotima Böttcher, Alexej Verkhratsky, Friedemann Paul, Fu‐Dong Shi, Tian Song   +13 more
wiley   +1 more source

Insights for Healthcare Providers on Shared Decision-Making in Multiple Sclerosis: A Narrative Review

Neurology and Therapy
Shared decision-making (SDM) between the patient and their healthcare provider (HCP) in developing treatment plans is increasingly recognized as central to improving treatment adherence and, ultimately, patient outcomes.
Sharon Stoll, Kathleen Costello, Scott D. Newsome, Hollie Schmidt, Amy B. Sullivan, Barry Hendin   +5 more
doaj   +1 more source

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations [PDF]

, 2017
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesA meta-analysis of publicly available summary statistics on multiple sclerosis ...
Aarsland, Dag, Alfredsson, Lars, Andreassen, Ole A., Benediktsson, Rafn, Bjarnason, Ragnar, Bjornsdottir, Unnur S., Bjornsson, Einar S, Bjornsson, Sigurdur, Bos, Steffan Daniël, Celius, Elisabeth G., Djurovic, Srdjan, Euesden, Jack, Fladby, Tormod, Geirsson, Arni J., Gislason, Thorarinn, Grondal, Gerdur, Gudbjartsson, Daniel F, Gustafsson, Omar, Harbo, Hanne F., Hillert, Jan, Hjaltason, Haukur, Ingason, Andres, Johannesson, Ari, Jonasson, Jon G., Jonsdottir, Ingileif, Jonsson, Stefan, Knudsen, Gun Peggy, Kockum, Ingrid Skelton, Kristjansdottir, Helga, Kristjansdottir, Sjofn, Ludviksson, Bjorn Runar, Masson, Gisli, Mikaelsdottir, Evgenia, Myhr, Kjell-Morten, Nilsson, Bjorn, Olafsson, Elias, Olafsson, Jon Hjaltalin, Olafsson, Sigurgeir, Olsson, Tomas, Orvar, Kjartan B., Rafnar, Thorunn, Sigurdsson, Snaevar, Sigurgeirsson, Bardur, Stefansson, Hreinn, Stefansson, Kari, Steinsson, Kristjan, Stridh, Pernilla, Sulem, Patrick, Thorleifsson, Gudmar, Thorsson, Arni V., Thorsteinsdottir, Unnur, Valdimarsson, Helgi, Valdimarsson, Trausti   +52 more
core   +1 more source

Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Multiple sclerosis (MS) patients often experience a higher incidence of clinical conditions before diagnosis, suggesting a prodromal phase. However, their predictive value and temporal trajectories remain underexplored. We investigated these aspects using the large UK Biobank's population‐based cohort, which provided clinical ...
Andrea Nova, Teresa Fazia, Giovanni Di Caprio, Davide Gentilini, Luisa Bernardinelli, Roberto Bergamaschi   +5 more
wiley   +1 more source