Results 91 to 100 of about 6,495,609 (392)
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
Science, 2019 Genetic roots of multiple sclerosis The genetics underlying who develops multiple sclerosis (MS) have been difficult to work out. Examining more than 47,000 cases and 68,000 controls with multiple genome-wide association studies, the International ...N. A. Patsopoulos, N. A. Patsopoulos, S. Baranzini, A. Santaniello, P. Shoostari, C. Cotsapas, G. Wong, Ashley H Beecham, T. James, J. Replogle, I. Vlachos, C. McCabe, T. Pers, T. Pers, A. Brandes, Charles A. White, B. Keenan, M. Cimpean, P. Winn, Ioannis-Pavlos Panteliadis, A. Robbins, Till F. M. Andlauer, O. Zarzycki, B. Dubois, A. Goris, H. Søndergaard, F. Sellebjerg, P. Sørensen, H. Ullum, L. Thørner, J. Saarela, I. Cournu-Rebeix, V. Damotte, B. Fontaine, L. Guillot-Noel, M. Lathrop, S. Vukusic, A. Berthele, Viola Pongratz, C. Gasperi, C. Graetz, V. Grummel, B. Hemmer, Muni Hoshi, B. Knier, T. Korn, C. Lill, F. Luessi, M. Muehlau, F. Zipp, E. Dardiotis, C. Agliardi, A. Amoroso, N. Barizzone, M. Benedetti, L. Bernardinelli, P. Cavalla, F. Clarelli, G. Comi, D. Cusi, F. Esposito, L. Ferré, D. Galimberti, C. Guaschino, M. Leone, V. Martinelli, L. Moiola, M. Salvetti, M. Sorosina, D. Vecchio, A. Zauli, S. Santoro, N. Mancini, M. Zuccalà, J. Mescheriakova, C. Duijn, S. Bos, E. Celius, A. Spurkland, M. Comabella, X. Montalban, L. Alfredsson, I. Bomfim, D. Gómez-Cabrero, J. Hillert, M. Jagodic, M. Lindén, F. Piehl, I. Jelcic, Roland Martin, M. Sospedra, A. Baker, M. Ban, C. Hawkins, P. Hysi, S. Kalra, F. Karpe, J. Khadake, G. Lachance, P. Molyneux, M. Neville, J. Thorpe, E. Bradshaw, S. Caillier, P. Calabresi, B. Cree, A. Cross, Mary F. Davis, P. D. Bakker, S. Delgado, M. Dembele, K. Edwards, K. Fitzgerald, I. Frohlich, P. Gourraud, J. Haines, H. Hakonarson, D. Kimbrough, N. Isobe, I. Konidari, E. Lathi, Michelle H. Lee, Tai-an Li, D. An, A. Zimmer, L. Madireddy, C. Manrique, M. Mitrovič, M. Olah, E. Patrick, M. Pericak-Vance, L. Piccio, C. Schaefer, H. Weiner, K. Lage, R. Scott, J. Lechner-Scott, R. Leal, P. Moscato, D. Booth, G. Stewart, S. Vucic, Grant Pame, Michael BamettO, D. Mason, L. Griffiths, S. Broadley, L. Tajouri, A. Baxter, M. Slee, B. Taylor, J. Charlesworth, T. Kilpatrick, J. Rubio, V. Jokubaitis, J. Wiley, H. Butzkueven, S. Leslie, A. Motyer, J. Stankovich, W. Carroll, A. Kermode, Marzena Edrin, M. Barclay, L. Peyrin-Biroulet, M. Chamaillard, J. Colombe, M. Cottone, A. Croft, R. D'Incà, J. Halfvarson, K. Hanigan, P. Henderson, J. Hugot, A. Karban, N. Kennedy, M. Khan, M. Lémann, A. Levine, D. Massey, M. Milla, Grant W. Motoey, S. M. Ng, Joannis Oikonomnou, H. Peeters, D. Proctor, J. Rahier, R. Roberts, P. Rutgeerts, F. Seibold, L. Stronati, K. Taylor, L. Törkvist, Kullak Ublick, J. V. Limbergen, A. Gossum, M. Vatn, Hu Zhang, Wei Zhang, P. Donnelly, I. Barroso, Jenefer M. Blackwe, E. Bramon, M. Brown, J. Casas, A. Corvin, P. Deloukas, A. Duncanson, Janusz Jankowski, H. Markus, C. Mathew, C. Palmer, R. Plomin, A. Rautanen, S. Sawcer, R. Trembath, A. Viswanathan, N. Wood, C. Spencer, G. Band, C. Bellenguez, C. Freeman, G. Hellenthal, E. Giannoulatou, M. Pirinen, R. Pearson, A. Strange, Zhan Sul, Damjan Vukcevic, C. Langford, S. Hunt, S. Edkins, R. Gwilliam, H. Blackburn, S. Bumpstead, S. Dronov, M. Gillman, Emma V. Gray, Naomi Hammond, Alagurevathi Jayakumar, O. T. McCann, J. Liddle, Simon C. Potter, Radhi Ravindrarajah, M. Ricketts, M. Waller, P. Weston, S. Widaa, P. Whittaker, Alastair Compston, D. Hafler, H. Harbo, S. Hauser, G. Stewart, S. D'alfonso, G. Hadjigeorgiou, B. E. Taylor, L. Barcellos, D. Booth, R. Hintzen, I. Kockum, F. Martinelli-Boneschi, J. McCauley, J. Oksenberg, A. Oturai, S. Sawcer, A. Ivinson, T. Olsson, P. Jager +268 moresemanticscholar +1 more source[Multiple sclerosis].
Der Radiologe, 2008 Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI.Grunwald, I, Kühn, A, Backens, M, Shariat, K, Kostopoulos, P, Papanagiotou, P +5 moreopenaire +3 more sourcesINF2‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background
INF2 mutations cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth disease (CMT). Accurate genetic diagnosis is critical, as INF2‐related FSGS is typically resistant to immunotherapy yet rarely recurs after transplantation, and its associated neuropathy can mimic treatable immune‐mediated disorders such as ...Chikashi Yano, Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Takahiro Hobara, Risa Nagatomo, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Chika Matsuoka, Toru Yamashita, Takashi Kimura, Ayako Miyazaki, Chinatsu Kinjo, Kenji Yokochi, Nanami Yamanaka, Nozomu Matsuda, Tomoki Suichi, Yoshiyuki Hanaoka, Haruka Kojima, Kenichi Todo, Hiroyuki Ishiura, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima +27 morewiley +1 more sourceA Case of Multiple Sclerosis Presenting as Eight and Half Syndrome. [PDF]
, 2013 Multiple sclerosis (MS) is a chronic disease characterized by inflammation, demyelination, gliosis (scarring), and neuronal loss; the course can be relapsing-remitting or progressive.Kaushik, M, Mahajan, SK, Raghav, S, Raina, R, Sharathbabu, NM +4 morecore “Brain age” predicts disability accumulation in multiple sclerosis [PDF]
, 2023 Matthew R. Brier, LI Zhuo-cheng, Maria Ly, Helmet T. Karim, Leda Liang, Weixin Du, John E. McCarthy, Anne H. Cross, Tammie L.S. Benzinger, Robert T. Naismith, Salim Chahin +10 moreopenalex +1 more sourceAnnual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab +10 morewiley +1 more sourceDissecting shared genetic architecture between obesity and multiple sclerosis [PDF]
, 2023 Ruijie Zeng, Rui Jiang, Wentao Huang, Jiaxuan Wang, Lijun Zhang, Yuying Ma, Yanjun Wu, Meijun Meng, Hekui Lan, Qizhou Lian, Felix W. Leung, Weihong Sha, Hao Chen +12 moreopenalex +1 more sourceExosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective
Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler +6 morewiley +1 more source