Results 1 to 10 of about 364,798 (230)

Smouldering multiple sclerosis: the ‘real MS’ [PDF]

Therapeutic Advances in Neurological Disorders, 2022
Using a philosophical approach or deductive reasoning, we challenge the dominant clinico-radiological worldview that defines multiple sclerosis (MS) as a focal inflammatory disease of the central nervous system (CNS).
Gavin Giovannoni, Veronica Popescu, Jens Wuerfel, Kerstin Hellwig, Ellen Iacobaeus, Michael B. Jensen, José Manuel García-Domínguez, Livia Sousa, Nicola De Rossi, Raymond Hupperts, Giuseppe Fenu, Benedetta Bodini, Hanna-Maija Kuusisto, Bruno Stankoff, Jan Lycke, Laura Airas, Cristina Granziera, Antonio Scalfari   +17 more
doaj   +8 more sources

Stepchild or Prodigy? Neuroprotection in Multiple Sclerosis (MS) Research [PDF]

International Journal of Molecular Sciences, 2015
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) and characterized by the infiltration of immune cells, demyelination and axonal loss. Loss of axons and nerve fiber pathology are widely accepted as correlates of neurological disability.
Andrea Rottlaender, Stefanie Küerten
openalex   +6 more sources

Familial Incidence of Multiple Sclerosis (MS)

Pediatric Neurology Briefs, 1988
Age-adjusted familial rates for MS were determined in children and siblings of patients studied at the MS Clinic and Dept of Genetics, Health Sciences Centre Hospital, Univ British Columbia, Vancouver BC, Canada.
J Gordon Millichap
doaj   +3 more sources

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Frontiers in Immunology, 2021
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, in which autoreactive T and B cells play important roles. Other lymphocytes such as NK cells and innate-like T cells appear to be involved as well.
Josefine Ruder, Jordan Rex, Simon Obahor, María José Docampo, Antonia M. S. Müller, Urs Schanz, Ilijas Jelcic, Roland Martin   +7 more
doaj   +1 more source

Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis

eLife, 2021
While transcripts of neuronal mitochondrial genes are strongly suppressed in central nervous system inflammation, it is unknown whether this results in mitochondrial dysfunction and whether an increase of mitochondrial function can rescue ...
Sina C Rosenkranz, Artem A Shaposhnykov, Simone Träger, Jan Broder Engler, Maarten E Witte, Vanessa Roth, Vanessa Vieira, Nanne Paauw, Simone Bauer, Celina Schwencke-Westphal, Charlotte Schubert, Lukas Can Bal, Benjamin Schattling, Ole Pless, Jack van Horssen, Marc Freichel, Manuel A Friese   +16 more
doaj   +1 more source

Improving Glucocorticoid Sensitivity of Brain-Homing CD4+ T Helper Cells by Steroid Hormone Crosstalk

Frontiers in Immunology, 2022
In early multiple sclerosis (MS), an IFN-γhighGM-CSFhighIL-17low CD4+ T-cell subset termed T helper 17.1 (Th17.1) reveals enhanced capacity to infiltrate the central nervous system. Th17.1 cells express high levels of multidrug resistance protein 1 (MDR1)
Steven C. Koetzier, Steven C. Koetzier, Jamie van Langelaar, Jamie van Langelaar, Annet F. Wierenga-Wolf, Annet F. Wierenga-Wolf, Marie-José Melief, Marie-José Melief, Kim Pol, Kim Pol, Suzanne Musters, Suzanne Musters, Erik Lubberts, Willem A. Dik, Willem A. Dik, Joost Smolders, Joost Smolders, Joost Smolders, Joost Smolders, Marvin M. van Luijn, Marvin M. van Luijn   +20 more
doaj   +1 more source

Klotho and vitamin D in multiple sclerosis: an Italian study [PDF]

, 2020
Introduction Low vitamin D levels have been recognised as an important risk factor for autoimmune diseases, including multiple sclerosis (MS). MS is a multifactorial disease, the pathogenesis of which contributes both to genetic and environmental ...
Bruna Lo Sasso, Caterina Maria Gambino, Chiara Bellia, Concetta Scazzone, Giorgia Iacolino, Giulia Bivona, Giuseppe Salemi, Luisa Agnello, Marcello Ciaccio, Paolo Ragonese, Sabrina Realmuto   +10 more
core   +1 more source

Podcast on the Challenges and Recommendations to Address Unmet Needs in MS for LGBTQ+ Populations in the United States

Neurology and Therapy, 2023
In general, individuals who are lesbian, gay, bisexual, transgender, queer or questioning, plus other identities (LGBTQ+) living with multiple sclerosis (MS) have less favorable healthcare experiences and poorer overall health than cisgendered ...
William L. Conte, Mark Cascione, Amy B. Sullivan   +2 more
doaj   +1 more source

Capturing hand tremors with a fuzzy logic wheelchair joystick controller [PDF]

, 1999
We have designed and built a fuzzy logic wheelchair controller which minimizes the effect of Multiple Sclerosis and tremors. The aim of our project has been to give people with Multiple Sclerosis better control of an electric wheelchair by removing ...
Corbett, Dan, Zwaag, Berend-Jan van der
core   +6 more sources

Advanced imaging for multiple sclerosis (ORP-14) [PDF]

Neurology Letters, 2023
This study focuses on the use of advanced imaging techniques for the assessment of multiple sclerosis (MS). The objective is to explore the potential of these imaging modalities in providing valuable insights into the pathophysiology and characterization
Elnaz Asadollahzadeh
doaj