Results 61 to 70 of about 466,412 (376)

Chances and challenges of a long-term data repository in multiple sclerosis: 20th birthday of the German MS registry

Scientific Reports, 2021
In 2001, the German Multiple Sclerosis Society, facing lack of data, founded the German MS Registry (GMSR) as a long-term data repository for MS healthcare research.
Lisa-Marie Ohle, David Ellenberger, Peter Flachenecker, Tim Friede, Judith Haas, Kerstin Hellwig, Tina Parciak, Clemens Warnke, Friedemann Paul, Uwe K. Zettl, Alexander Stahmann   +10 more
doaj   +1 more source

Predicting multiple sclerosis disease severity with multimodal deep neural networks [PDF]

arXiv, 2023
Multiple Sclerosis (MS) is a chronic disease developed in human brain and spinal cord, which can cause permanent damage or deterioration of the nerves. The severity of MS disease is monitored by the Expanded Disability Status Scale (EDSS), composed of several functional sub-scores.
arxiv  

Can we prevent or treat multiple sclerosis by individualised vitamin D supply? [PDF]

, 2013
Apart from its principal role in bone metabolism and calcium homeostasis, vitamin D has been attributed additional effects including an immunomodulatory, anti-inflammatory, and possibly even neuroprotective capacity which implicates a possible role of ...
A Ascherio, A Ascherio, A Ascherio, A Boonstra, A Compston, A Döring, A Kutzelnigg, A Nylander, AD Sadovnick, AE Handel, AE Handel, AE Handel, AK Bhalla, B Banwell, B Hintzpeter, BD Mahon, BD Trapp, BR Becklund, C Almerighi, C Carlberg, C Pierrot-Deseilligny, C Veauthier, CH Polman, CJ Willer, D Buck, DA Dyment, DAF de Abreu, DG Haegert, DM Wingerchuk, DP Auer, DS Goodin, DS Meier, DW Eyles, E Garcion, E Peelen, ED Acheson, EM Mowry, EM Mowry, F Dalmay, F Mirzaei, F Paul, G Giovannoni, H Tremlett, HA Bischoff-Ferrari, HF Deluca, HF McFarland, IAF Van der Mei, IAF Van der Mei, J Aivo, J Correale, J Dörr, J Dörr, J Río, J Salzer, J Smolders, J Smolders, J Vogt, JC Fleet, JC Souberbielle, JF Kurtzke, JF Kurtzke, JF Marcus, JH White, JM Burton, JM Lemire, JM Lemire, JN Hathcock, JW Peterson, KI Løken-Amsrud, KL Munger, KL Munger, KM Spach, L Grimaldi, L Piemonti, LB Pedersen, M Bock, M Di Rosa, M Soilu-Hänninen, M Soilu-Hänninen, MD Griffin, MF Holick, MF Holick, MF Holick, MF Holick, MK Thomas, MR Haussler, MS Stein, MT Cantorna, MT Kampman, MT Kampman, N Borisow, N De Stefano, N Jain, N Weinges-Evers, O Golubnitschaja, P Goldberg, PH Hart, PS Sorensen, R Dobson, RJ Fox, RL Swank, RM Lucas, S Chen, S Simpson Jr, S Sotgiu, S Wergeland, S Yu, SM Kimball, SV Ramagopalan, SV Ramagopalan, SV Ramagopalan, SV Ramagopalan, T Hagenau, T Holmøy, T Islam, T Oberwahrenbrock, T Sinnecker, T Sinnecker, TF Runia, TY McDowell, TY McDowell, V Limmroth, V Shaygannejad, VA Jagannath, WB Grant, Y Jin, Ø Torkildsen   +126 more
core   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Patient level dataset to study the effect of COVID-19 in people with Multiple Sclerosis

Scientific Data
Multiple Sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system, causing increased vulnerability to infections and disability among young adults. Ever since the outbreak of coronavirus disease 2019 (COVID-19), caused by severe
Hamza Khan, Lotte Geys, Peer Baneke, Giancarlo Comi, Liesbet M. Peeters   +4 more
doaj   +1 more source

Multiple Sclerosis and cognitive dysfunctions [PDF]

, 2019
Multiple Sclerosis (MS) is the most common neurological disease worldwide. The article presents the symptoms, the etiology and the diagnosis of MS. It also refers to the neuropsychological data and cognitive disorders in Multiple Sclerosis, to the MS ...
Adamou, Christina, Dardavessis, Theodoros   +1 more
core   +1 more source

Potential pathogens in multiple sclerosis (MS

Postępy Higieny i Medycyny Doświadczalnej, 2012
 Multiple sclerosis is a neuroimmunological disease in which etiologic agents have not been identified yet. The etiology of MS is complex in its nature and may involve many different agents acting simultaneously or in a cascade manner leading to the development of the disease.
openaire   +3 more sources

Inflammatory disease in people with multiple sclerosis treated with immune checkpoint inhibitors

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 643-647, March 2025.
Abstract This study evaluated disease activity in people with Multiple Sclerosis (PwMS) who received immune checkpoint inhibitors (ICIs) compared to PwMS not treated with ICIs. There were 108 PwMS included (27 PwMS+ICIs and 81 PwMS controls), matched on age, sex, disease duration, DMTs, and MS disease course. Of 27 PwMS+ICIs, one (4%) had a relapse and
Saira Afzal, Yadi Li, Brittany Lapin, Le H. Hua, Lucy Boyce Kennedy, Wen Wee Ma, Marisa McGinley, Jeffrey A. Cohen, Amy Kunchok   +8 more
wiley   +1 more source

Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS

Journal of Neuroinflammation, 2017
Background Laquinimod is an oral immunomodulator in clinical development to treat relapsing-remitting multiple sclerosis (RRMS). Laquinimod is in clinical development for the treatment of multiple sclerosis and Huntington Disease (HD).
Tjalf Ziemssen, Hayrettin Tumani, Tony Sehr, Katja Thomas, Friedemann Paul, Nils Richter, Emil Samara, Ofer Spiegelstein, Ella Sorani, Oren Bar-Ilan, Dorit Mimrod, Liat Hayardeny   +11 more
doaj   +1 more source

Pediatric, adult, and late onset multiple sclerosis: Cognitive phenotypes and gray matter atrophy

Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 512-522, March 2025.
Abstract Objectives We aim to investigate cognitive phenotype distribution and MRI correlates across pediatric‐, elderly‐, and adult‐onset MS patients as a function of disease duration. Methods In this cross‐sectional study, we enrolled 1262 MS patients and 238 healthy controls, with neurological and cognitive assessments.
Ermelinda De Meo, Emilio Portaccio, Rosa Cortese, Luis Ruano, Benedetta Goretti, Claudia Niccolai, Francesco Patti, Clara Chisari, Paolo Gallo, Paola Grossi, Angelo Ghezzi, Marco Roscio, Flavia Mattioli, Chiara Stampatori, Marta Simone, Rosa Gemma Viterbo, Raffaello Bonacchi, Assunta Maria Rocca, Elisa Leveraro, Antonio Giorgio, Nicola De Stefano, Massimo Filippi, Matilde Inglese, Maria Pia Amato   +23 more
wiley   +1 more source