Results 71 to 80 of about 466,412 (376)
Comparison of Time-to-First-Event and Recurrent Event Methods in Multiple Sclerosis Trials [PDF]
arXiv, 2021 Suppression of disability progression is an important goal in the treatment of multiple sclerosis (MS). Randomized clinical trials in MS frequently use the time to the first confirmed disability progression (CDP) on the ordinal Expanded Disability Status Scale (EDSS) as an endpoint.
arxiv
Using IMPrESS to guide policy change in multiple sclerosis [PDF]
, 2017 The International MultiPlE Sclerosis Study (IMPrESS) studied the significant impact of multiple sclerosis (MS) on the health and well-being of both people with the disease and their caregivers, along with its broader socioeconomic impact.
Efthymiadou, Olina +5 more
core +1 more source
The genetic basis of multiple sclerosis: a model for MS susceptibility [PDF]
BMC Neurology, 2010 MS-pathogenesis is known to involve both multiple environmental events, and several independent genetic risk-factors.A model of susceptibility is developed and a mathematical analysis undertaken to elucidate the nature of genetic susceptibility to MS and to understand the constraints that are placed on the genetic basis of MS, both by the known ...
openaire +6 more sources
Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 523-537, March 2025.Abstract Objective To characterize structural integrity of the lumbosacral enlargement and conus medullaris within one month after spinal cord injury (SCI). Methods Lumbosacral cord MRI data were acquired in patients with sudden onset (<7 days) SCI at the cervical or thoracic level approximately one month after injury and in healthy controls.
Silvan Büeler +15 more
wiley +1 more source
Escalation or high-efficacy disease-modifying therapies in multiple sclerosis [PDF]
Neurology Letters, 2023 Elnaz Asadollahzadeh
doaj +1 more source
Brain SciencesBackground/Objectives: Changes in nuclear morphology, alterations to the nuclear pore complex (NPC), including loss, aggregation, and dysfunction of nucleoporins (Nups), and nucleocytoplasmic transport (NCT) abnormalities have become hallmarks of ...
Todd E. Stang +4 more
doaj +1 more source
Lesion-Specific Prediction with Discriminator-Based Supervised Guided Attention Module Enabled GANs in Multiple Sclerosis [PDF]
arXiv, 2022 Multiple Sclerosis (MS) is a chronic neurological condition characterized by the development of lesions in the white matter of the brain. T2-fluid attenuated inversion recovery (FLAIR) brain magnetic resonance imaging (MRI) provides superior visualization and characterization of MS lesions, relative to other MRI modalities. Follow-up brain FLAIR MRI in
arxiv
Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 805-820, April 2025.Abstract Objectives This study sought to evaluate proteomic, metabolomic, and immune signatures in the cerebrospinal fluid of individuals with Down Syndrome Regression Disorder (DSRD). Methods A prospective case–control study comparing proteomic, metabolomic, and immune profiles in individuals with DSRD was performed.
Jonathan D. Santoro +12 more
wiley +1 more source
Segmentation of Multiple Sclerosis Lesions across Hospitals: Learn Continually or Train from Scratch? [PDF]
arXiv, 2022 Segmentation of Multiple Sclerosis (MS) lesions is a challenging problem. Several deep-learning-based methods have been proposed in recent years. However, most methods tend to be static, that is, a single model trained on a large, specialized dataset, which does not generalize well.
arxiv
The Causal Cascade to Multiple Sclerosis: A Model for MS Pathogenesis [PDF]
PLoS ONE, 2009 MS pathogenesis seems to involve both genetic susceptibility and environmental risk factors. Three sequential factors are implicated in the environmental risk. The first acts near birth, the second acts during childhood, and the third acts long thereafter. Two candidate factors (vitamin D deficiency and Epstein-Barr viral infection) seem well suited to
openaire +6 more sources