Results 131 to 140 of about 483,132 (293)
A comprehensive comparison of comparative RNA structure prediction approaches
, 2004 Gardner PP, Giegerich R. A comprehensive comparison of comparative RNA structure prediction approaches. BMC Bioinformatics. 2004;5(1): 140.Background: An increasing number of researchers have released novel RNA structure analysis and prediction ...
Giegerich, R. +7 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Design and Implement of Multiple EST to Genome Alignment
, 2009 [[abstract]]Expressed Sequence Tag (EST) is the key that we know the function of the organism. Through the EST analysis, we’ll understand the information of the alternative splicing, SNP, gene structure, etc. The multiple sequence alignment (MSA) problem
Wei-Chung Shia
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
HMMerge: an ensemble method for multiple sequence alignment. [PDF]
Bioinform Adv, 2023 Park M, Warnow T.
europepmc +1 more source
Multiple sequence alignment of neuropeptides.
, 2014 Multiple sequence alignment of neuropeptides.
Ming Yang (109148) +4 more
core +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Multiple sequence alignment based on deep reinforcement learning with self-attention and positional encoding. [PDF]
Bioinformatics, 2023 Liu Y +6 more
europepmc +1 more source
Practical multiple Sequence alignment
, 2010 Multiple sequence alignment as a means of comparing DNA, RNA or amino acid sequences is an essential precondition for various analyses, including structure prediction, modeling binding sites, phylogeny or function prediction.
Reinert, K. +3 more
core +1 more source