Results 111 to 120 of about 6,883,088 (299)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2012 Multiple sequence alignment of DNA sequence data for mitochondrial 16S ribosomal RNA ...
David C. Blackburn (244228)
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
P-Coffee: A New Divide-and-conquer Method for Multiple Sequence Alignment
, 2005 We describe a new divide-and-conquer method, P-Coffee, for alignment of multiple sequences. P-Coffee first identifies candidate alignment columns using a position-specific substitution matrix (the T-Coffee extended library), tests those columns, and ...
Choi, Kwangbom
core
Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets [PDF]
, 2012 Hoffmann N, Keck M, Neuweger H, et al. Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets. BMC Bioinformatics.
Keck, Matthias +8 more
core +1 more source
Multiple sequence alignment of TP0136.
, 2021 Multiple sequence alignment for all amino acid sequence variants. Polymorphic residues are highlighted. (TIF)
Sheila A. Lukehart (11402249) +32 more
core +1 more source
Kalign – an accurate and fast multiple sequence alignment algorithm
BMC Bioinformatics, 2005 Background The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families for conserved motifs, phylogeny, structural properties, and to improve ...
Sonnhammer Erik LL, Lassmann Timo
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Multiple sequence alignment based on structural properties [PDF]
, 2010 A multiple sequence alignment (MSA) is a sequence alignment of three or more biological sequences. Main idea behind multiple sequence alignment is to see the similarities between input sequences, to be able to make phylogenetic analysis and other ...
Bugra Ozer +7 more
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source