Results 111 to 120 of about 483,132 (293)
Vertical decomposition with Genetic Algorithm for Multiple Sequence Alignment
BMC Bioinformatics, 2011 Background Many Bioinformatics studies begin with a multiple sequence alignment as the foundation for their research. This is because multiple sequence alignment can be a useful technique for studying molecular evolution and analyzing sequence structure ...
Essam Daryl +2 more
doaj +1 more source
P-Coffee: A New Divide-and-conquer Method for Multiple Sequence Alignment
, 2005 We describe a new divide-and-conquer method, P-Coffee, for alignment of multiple sequences. P-Coffee first identifies candidate alignment columns using a position-specific substitution matrix (the T-Coffee extended library), tests those columns, and ...
Choi, Kwangbom
core
Multiple sequence alignment of TP0326.
, 2021 Multiple sequence alignment for all amino acid sequence variants. Polymorphic residues are highlighted, and positions of extracellular loops 3, 4, and 7 are shown. (TIF)
Sheila A. Lukehart (11402249) +32 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Automatic detection of anchor points for multiple sequence alignment
BMC Bioinformatics, 2010 Background Determining beforehand specific positions to align (anchor points) has proved valuable for the accuracy of automated multiple sequence alignment (MSA) software.
Pitschi Florian +2 more
doaj +1 more source
, 2013 Multiple sequence alignment of the SEF amino acid sequence from Amblyomma maculatum, Rhipicephalus pulchellus, Culex quinquefasciatus, Drosophila melanogaster, and Homo sapiens.
Shahid Karim (191874) +4 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Kalign – an accurate and fast multiple sequence alignment algorithm
BMC Bioinformatics, 2005 Background The alignment of multiple protein sequences is a fundamental step in the analysis of biological data. It has traditionally been applied to analyzing protein families for conserved motifs, phylogeny, structural properties, and to improve ...
Sonnhammer Erik LL, Lassmann Timo
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source