Results 141 to 150 of about 483,132 (293)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

MULTIPLE SEQUENCE ALIGNMENT MENGGUNAKAN HIDDEN MARKOV MODEL

, 2015
Mudah dan murahnya proses pengumpulan data biologi molekuler saat ini menyebabkan ukuran basis data genetika meningkat dengan pesat. Hal ini meningkatkan kebutuhan akan alat bantu komputasi untuk menganalisa data tersebut.
Afiahayati, Afiahayati, Mulyana, Sri
core   +1 more source

Global Network Alignment

, 2010
Motivation: High-throughput methods for detecting molecular interactions have lead to a plethora of biological network data with much more yet to come, stimulating the development of techniques for biological network alignment.
Oleksii Kuchaiev, Natasa Przulj
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Abalign: a comprehensive multiple sequence alignment platform for B-cell receptor immune repertoires. [PDF]

Nucleic Acids Res, 2023
Zong F, Long C, Hu W, Chen S, Dai W, Xiao ZX, Cao Y.   +6 more
europepmc   +1 more source

CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure

, 2012
Background: One aim of the in silico characterization of proteins is to identify all residue-positions, which are crucial for function or structure. Several sequence-based algorithms exist, which predict functionally important sites.
Kück, Fabian, Rainer Merkl, Merkl, Rainer, Fabian Kück, Busch, Markus, Porfenenko, Mikhail, Mikhail Porfenenko, Merkl Rainer, Jan-Oliver Janda, Kück Fabian, Janda, Jan-Oliver, Porfenenko Mikhail, Janda Jan-Oliver, Busch Markus, Markus Busch   +14 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sequence Flow: interactive web application for visualizing partial order alignments

BMC Genomics
Background Multiple sequence alignment (MSA) has proven extremely useful in computational biology, especially in inferring evolutionary relationships via phylogenetic analysis and providing insight into protein structure and function.
Krzysztof Zdąbłasz, Anna Lisiecka, Norbert Dojer   +2 more
doaj   +1 more source

Improved mammalian family phylogeny using gap-rare multiple sequence alignment: A timetree of extant placentals and marsupials. [PDF]

Zool Res, 2023
Liu GM, Pan Q, Du J, Zhu PF, Liu WQ, Li ZH, Wang L, Hu CY, Dai YC, Zhang XX, Zhang Z, Yu Y, Li M, Wang PC, Wang X, Li M, Zhou XM.   +16 more
europepmc   +1 more source

Divide-and-Conquer Multiple Sequence Alignment

, 1997
Contents 1 Introduction 1 1.1 Preliminaries . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.3 Acknowledgements . . . . . . . . . . . . . . . . . . . . .
Gerhard Sagerer, Jens Stoye, Technischen Fakultat, Ipke Wachsmuth, Doktors Der Naturwissenschaften, Helge Ritter, Abteilung Informationstechnik, Impressum Herausgeber, Alois Knoll, Robert Giegerich, Peter Ladkin, Bielefeld Im Januar   +11 more
core