Results 161 to 170 of about 1,526,772 (381)

Instability in progressive multiple sequence alignment algorithms

Algorithms for Molecular Biology, 2015
Progressive alignment is the standard approach used to align large numbers of sequences. As with all heuristics, this involves a tradeoff between alignment accuracy and computation time.
Kieran Boyce, Fabian Sievers, D. Higgins
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

A comparative analysis of progressive multiple sequence alignment approaches using UPGMA and neighbor joining based guide trees [PDF]

International Journal of Computer Science, Engineering and Information Technology (IJCSEIT), Vol. 5,No.3/4, August 2015, 2015
Multiple sequence alignment is increasingly important to bioinformatics, with several applications ranging from phylogenetic analyses to domain identification. There are several ways to perform multiple sequence alignment, an important way of which is the progressive alignment approach studied in this work.
arxiv  

Comparative analysis of multiple protein-sequence alignment methods. [PDF]

, 1994
Marcella A. McClure, T K Vasi, W M Fitch
openalex   +1 more source

Process-oriented Iterative Multiple Alignment for Medical Process Mining

, 2017
Adapted from biological sequence alignment, trace alignment is a process mining technique used to visualize and analyze workflow data. Any analysis done with this method, however, is affected by the alignment quality.
Burd, Randall S., Chen, Shuhong, Marsic, Ivan, Yang, Sen, Zhou, Moliang   +4 more
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Zero Knowledge Proof for Multiple Sequence Alignment [PDF]

arXiv
Multiple sequence alignment (MSA) is a fundamental algorithm in bioinformatics. In a situation when the alignment might need to be protected while revealing the other information such the input sequences and the alignment score, zero knowledge proof can be used.
arxiv  

Multiple Sequence Alignment While Assessing Saturation Across Sequence Data [PDF]

, 2017
Constructing and analyzing phylogenetic trees is central to biological disciplines such as evolutionary and systematic biology. Accurate phylogenetic inference improves the estimation of evolutionary relationships, rates of molecular evolution, and ...
Pearse, William D., Weedop, K. Bodie
core   +1 more source

Molecular homology and multiple-sequence alignment: an analysis of concepts and practice

Australian Systematic Botany, 2015
. Sequence alignment is just as much a part of phylogenetics as is tree building, although it is often viewed solely as a necessary tool to construct trees.
D. Morrison, M. Morgan, S. Kelchner
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source