The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. [PDF]
Our previous studies had shown that DAZAP2 was profoundly downregulated in bone marrow mononuclear cells from multiple myeloma patients. In this report, we analyzed epigenetic changes in multiple myeloma cell lines to understand the molecular mechanisms ...
Sai-Qun Luo +7 more
doaj +1 more source
Management of panfacial and complex facial fractures: A Belgaum perspective – Case series
Multiple facial bone fractures usually are consequential to severe injuries secondary to motor vehicle calamities. These complex and panfacial fractures are usually associated with multiple systemic injuries that mandate a multidisciplinary approach to ...
Vijaylaxmi Shettar +4 more
doaj +1 more source
Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack +12 more
wiley +1 more source
Ultra-short-term and Short-term Power Load Single-step and Multi-step Prediction Considering Spatial Association [PDF]
Accurate ultra-short-term and short-term multi-region power load forecasting is the key to achieving rapid response and real-time scheduling in power systems.
GENG Zhenwei, LI Shenzhang, YU Fengrong
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Multivariate time series forecasting is widely used in various fields in real life. Many time series prediction models have been proposed. The current forecasting model lacks the mining of correlation between sequences based on different periods and ...
WenChang Zhang +5 more
doaj +1 more source
Emergence of functional hierarchy in a multiple timescale neural network model: a humanoid robot experiment. [PDF]
It is generally thought that skilled behavior in human beings results from a functional hierarchy of the motor control system, within which reusable motor primitives are flexibly integrated into various sensori-motor sequence patterns.
Yuichi Yamashita, Jun Tani
doaj +1 more source
Pseudostarlikeness and Pseudoconvexity of Multiple Dirichlet Series
Let $p\in {\Bbb N}$, $s=(s_1,\ldots,s_p)\in {\Bbb C}^p$, $h=(h_1,\ldots,h_p)\in {\Bbb R}^p_+$, $(n)=(n_1,\ldots,n_p)\in {\Bbb N}^p$ and the sequences $\lambda_{(n)}=(\lambda^{(1)}_{n_1},\ldots,\lambda^{(p)}_{n_p})$ are such that $0<\lambda^{(j)}_1 ...
Myroslav Sheremeta
doaj +1 more source
H5N1 Clade 2.2 Polymorphism Tracing Identifies Influenza Recombination and Potential Vaccine Targets [PDF]
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 2.
A Abdelghani +15 more
core +3 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source

