Results 61 to 70 of about 1,205,232 (260)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Entropy of Entropy: Measurement of Dynamical Complexity for Biological Systems

Entropy, 2017
Healthy systems exhibit complex dynamics on the changing of information embedded in physiologic signals on multiple time scales that can be quantified by employing multiscale entropy (MSE) analysis.
Chang Francis Hsu, Sung-Yang Wei, Han-Ping Huang, Long Hsu, Sien Chi, Chung-Kang Peng   +5 more
doaj   +1 more source

INTEGRATION OF TERRESTRIAL LASER SCANNING POINTS AND 2D FLOOR PLANS BASED ON MAXIMUM SEQUENTIAL SIMILARITY [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2012
This paper presents a Maximum Sequential Similarity Reasoning (MSSR) algorithm based method for co-registration of 3D TLS data and 2D floor plans. The co-registration consists of two tasks: estimating a transformation between the two datasets and finding
L. Wang, G. Sohn
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

AMDCnet: attention-gate-based multi-scale decomposition and collaboration network for long-term time series forecasting

Frontiers in Artificial Intelligence
IntroductionTime series analysis plays a critical role in various applications, including sensor data monitoring, weather forecasting, economic predictions, and network traffic management. While traditional methods primarily focus on modeling time series
Shikang Hou, Song Sun, Tao Yin, Zhibin Zhang, Meng Yan   +4 more
doaj   +1 more source

Evaluating parametric holonomic sequences using rectangular splitting

, 2013
We adapt the rectangular splitting technique of Paterson and Stockmeyer to the problem of evaluating terms in holonomic sequences that depend on a parameter. This approach allows computing the $n$-th term in a recurrent sequence of suitable type using $O(
Johansson, Fredrik
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

State of Health Estimation for Lithium-ion Batteries Based on Fusion of Autoregressive Moving Average Model and Elman Neural Network

IEEE Access, 2019
This paper proposes a fusion model based on the autoregressive moving average (ARMA) model and Elman neural network (NN) to achieve accurate prediction for the state of health (SOH) of lithium-ion batteries.
Zheng Chen, Qiao Xue, Renxin Xiao, Yonggang Liu, Jiangwei Shen   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source