Results 51 to 60 of about 1,205,232 (260)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Unsupervised Spoken Term Detection with Spoken Queries by Multi-level Acoustic Patterns with Varying Model Granularity

open access: yes, 2015
This paper presents a new approach for unsupervised Spoken Term Detection with spoken queries using multiple sets of acoustic patterns automatically discovered from the target corpus.
Chan, Chun-an   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A novel fast target tracking method for UAV aerial image

open access: yesOpen Physics, 2017
Unmanned aerial vehicles (UAV) are able to achieve autonomous flight without drivers, and UAV has been a key tool to extract space data. Therefore, how to detect the trajectories of targets from UAV aerial image sequences is of great importance.
Jianfang Liu, Hao Zheng, Jingli Gao
doaj   +1 more source

Measuring Shared Information and Coordinated Activity in Neuronal Networks [PDF]

open access: yes, 2005
Most nervous systems encode information about stimuli in the responding activity of large neuronal networks. This activity often manifests itself as dynamically coordinated sequences of action potentials.
Camperi, Marcelo F.   +2 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Identifying Actionable Serial Correlations in Financial Markets

open access: yesFrontiers in Applied Mathematics and Statistics, 2021
Financial markets are complex systems where information processing occurs at multiple levels. One signature of this information processing is the existence of recurrent sequences.
Siew Ann Cheong   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Automated Detection of Paroxysmal Atrial Fibrillation Using an Information-Based Similarity Approach

open access: yesEntropy, 2017
Atrial fibrillation (AF) is an abnormal rhythm of the heart, which can increase heart-related complications. Paroxysmal AF episodes occur intermittently with varying duration.
Xingran Cui   +5 more
doaj   +1 more source

Forecasting Scenario Generation for Multiple Wind Farms Considering Time-series Characteristics and Spatial-temporal Correlation

open access: yesJournal of Modern Power Systems and Clean Energy, 2021
Scenario forecasting methods have been widely studied in recent years to cope with the wind power uncertainty problem. The main difficulty of this problem is to accurately and comprehensively reflect the time-series characteristics and spatial-temporal ...
Qingyu Tu   +7 more
doaj   +1 more source

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