Results 111 to 120 of about 17,215,808 (337)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
On some variational algebraic problems
Advances in Nonlinear Analysis, 2013 In this paper by exploiting critical point theory, the existence of two distinct nontrivial solutions for a nonlinear algebraic system with a parameter is established.
Molica Bisci Giovanni, Repovš Dušan
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Multiple solutions for a discrete anisotropic (p_1(k),p_2(k))-Laplacian equations
Electronic Journal of Differential Equations, 2015 This article concerns the existence and multiplicity solutions for a discrete Dirichlet Laplacian problems. Our technical approach is based on variational methods.
El Miloud Hssini
doaj
Evidence for a dual-process account of over-imitation: Children imitate anti- and prosocial models equally, but prefer prosocial models once they become aware of multiple solutions to a task. [PDF]
PLoS One, 2021 Schleihauf H, Hoehl S.
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Existence and multiplicity of solutions for nonhomogeneous Klein-Gordon-Maxwell equations
Electronic Journal of Differential Equations, 2015 This article concerns the nonhomogeneous Klein-Gordon-Maxwell equation $$\displaylines{ -\Delta u+u-(2\omega +\phi)\phi u=|u|^{p-1}u +h(x), \quad\text{in }\mathbb{R}^3,\cr \Delta \phi=(\omega +\phi)u^2,\quad\text{in }\mathbb{R}^3, }$$ where ...
Liping Xu, Haibo Chen
doaj
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source