Results 111 to 120 of about 73,056 (308)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Too fast to be single: Tidal evolution and photometric identification of stellar and planetary companions

The Open Journal of Astrophysics
Many stars exist in binary or multiple systems where tidal interactions modify rotational evolution. In single stars, Many stars, including those in binary or multiple systems, exhibit modified rotational evolution due to tidal interactions.
Ilay Kamai, Hagai B. Perets
doaj   +1 more source

CCD photometry and astrometry for visual double and multiple stars of the HIPPARCOS catalogue [PDF]

, 2001
P. Lampens, E. Oblak, D. Duval, M. Chareton   +3 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Some Thoughts on Multiple Stars [PDF]

, 1977
David S. Evans
openalex   +1 more source

The GALAH survey: Multiple stars and our Galaxy. I. A comprehensive method for deriving properties of FGK binary stars [PDF]

, 2020
G. Traven, S. Feltzing, T. Merle, M. Van der Swaelmen, Klemen Čotar, Ross P. Church, T. Zwitter, Yuan-Sen Ting, C. Sahlholdt, M. Asplund, Joss Bland‐Hawthorn, G. De Silva, K. C. Freeman, Sarah L. Martell, Sanjib Sharma, D. B. Zucker, Sven Buder, Andrew R. Casey, V. D’Orazi, Janez Kos, Geraint F. Lewis, J. Lin, K. Lind, Jeffrey D. Simpson, Dennis Stello, U. Munari, Robert A. Wittenmyer   +26 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Southern Binaries with the Zorro Speckle Camera @ Gemini South

The Astronomical Journal
We present measurements in the context of a survey of southern hemisphere binary and multiple stellar systems observed with the Zorro Speckle dual diffraction-limited optical imaging camera on the 8.1 m Gemini South telescope carried out between 2019 and
Rene A. Mendez, Andrei Tokovinin, Edgardo Costa, Maximiliano Dirk   +3 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source