Results 121 to 130 of about 5,074,994 (301)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Astrophysical JournalJames Webb Space Telescope (JWST) observations have been demonstrated to be efficient in detecting multiple stellar populations in globular clusters (GCs) in the low-mass regime of M dwarfs.
A. F. Marino +16 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
On the eigenvalues multiplicity function of the star graph
Sibirskie Elektronnye Matematicheskie Izvestiya, 2018 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Photometric Identification of Unresolved Binary Stars in Nearby Open Star Clusters
The Astrophysical JournalThis paper introduces a new method to search for unresolved binary stars in open star clusters. The work aims at improving the approach introduced previously, which employs the (H − W2) − W1 versus W2 − (BP − K) photometric diagram.
Varvara O. Mikhnevich +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Populations of Planets in Multiple Star Systems [PDF]
, 2018 Invited review chapter, accepted for publication in "Handbook of Exoplanets", ed. H. Deeg & J.
openaire +2 more sources
The Astrophysical Journal LettersMetal-poor stars enriched by a single supernova (mono-enriched stars) are direct proof (and provide valuable probes) of supernova nucleosynthesis. Photometric and spectroscopic observations have shown that metal-poor stars have a wide variety of chemical
Yutaka Hirai +4 more
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