Results 121 to 130 of about 508,501 (339)

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

The Effect of Stellar Rotation on Colour-Magnitude Diagrams: On the apparent presence of multiple populations in intermediate age stellar clusters

, 2009
A significant number of intermediate age clusters (1-2 Gyr) in the Magellanic Clouds appear to have multiple stellar populations within them, derived from bi-modal or extended main sequence turn offs. If this is interpreted as an age spread, the multiple
Bekki, Boesgaard, Cardini, Charbonnel, Collins, D'Ercole, D'Souza, De Mink, Donati, Eldridge, Faulkner, Fossati, Gaige, Glatt, Goudfrooij, Gray, Heger, Huang, Huang, Hunter, Mackey, Mackey, Massey, Mestel, Meynet, Milone, N. Bastian, Palacios, Pietrinferni, Piotto, Pérez Hernández, Royer, S. E. de Mink, Salpeter, Schatzman, Talon, Townsend, von Zeipel, Westera, Yoon   +39 more
core   +1 more source

Probing the distinct chemical history of the Milky Way halo and old thick disk through HESP-GOMPA survey [PDF]

EPJ Web of Conferences
Recent studies of the time-resolved Milky Way formation using asteroseismology have shown that thick disk stars could be very old (0.8 Gyr after the Big Bang, even older than the inner halo).
Saraf Pallavi, Sivarani Thirupathi, Bandyopadhyay Avrajit   +2 more
doaj   +1 more source

Populations of Planets in Multiple Star Systems [PDF]

, 2018
Invited review chapter, accepted for publication in "Handbook of Exoplanets", ed. H. Deeg & J.
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Low-mass Stellar and Substellar Candidate Companions around Massive Stars in Sco OB1 and M17

The Astronomical Journal
Massive stars are recognized for their high degree of multiplicity, yet the mass ratio regime below 0.1 remains insufficiently explored. It is therefore unknown whether extremely low-mass (possibly substellar) companions can form and survive in the ...
Tinne Pauwels, Maddalena Reggiani, Hugues Sana, Laurent Mahy   +3 more
doaj   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Notes on “A Catalogue of 10,300 Multiple and Double Stars &c.,” forming Vol. XL of the Memoirs of the Royal Astronomical Society [PDF]

, 1880
H. Sadler
openalex   +1 more source

Symmetrization of the Berezin star product and multiple star product method [PDF]

Journal of Physics A: Mathematical and General, 2001
We construct a multiple star product method and by using this method, show that integral forms of some star products can be written in terms of the path-integral. This method can be applied to some examples. Especially, the associativity of the skew-symmetrized Berezin star product proposed in \cite{SW}, is recovered in large $N$ limit of the multiple ...
openaire   +5 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source