Results 131 to 140 of about 6,328,275 (332)
TOWARD A DETERMINISTIC MODEL OF PLANETARY FORMATION. VI. DYNAMICAL INTERACTION AND COAGULATION OF MULTIPLE ROCKY EMBRYOS AND SUPER-EARTH SYSTEMS AROUND SOLAR-TYPE STARS [PDF]
Shigeru Ida, D. N. C. Lin
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Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Multiple and changing cycles of active stars [PDF]
Z. Kolláth, Katalin Oláh
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This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
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James Webb Space Telescope (JWST) observations have been demonstrated to be efficient in detecting multiple stellar populations in globular clusters (GCs) in the low-mass regime of M dwarfs.
A. F. Marino +16 more
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The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Metal-poor stars enriched by a single supernova (mono-enriched stars) are direct proof (and provide valuable probes) of supernova nucleosynthesis. Photometric and spectroscopic observations have shown that metal-poor stars have a wide variety of chemical
Yutaka Hirai +4 more
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Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source

