Results 211 to 220 of about 508,501 (339)

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Increased complexity of social category markers leads to diverse rule-based categorizations and reduced intergroup bias. [PDF]

Proc Biol Sci
Hertz U.
europepmc   +1 more source

Spatial mixing of binary stars in multiple-population globular clusters [PDF]

, 2018
Jongsuk Hong, Saahil Patel, Enrico Vesperini, Jeremy J. Webb, E. Dalessandro   +4 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

MINISTAR to STARLITE: Evolution of a Miniaturized Prototype for Testing Attitude Sensors. [PDF]

Sensors (Basel)
Nardino V, Baccani C, Ceccherini M, Cecchi M, Focardi F, Franci E, Guzzi D, Manna F, Milli V, Pini J, Salvadori L, Raimondi V.   +11 more
europepmc   +1 more source

Supermassive stars as the origin of the multiple populations in globular clusters [PDF]

, 2019
Mark Gieles, C. Charbonnel
openalex   +1 more source

MOCCA: Dynamics and evolution of binary stars of multiple stellar populations in tidally filling and underfilling globular star clusters

, 2022
Arkadiusz Hypki, Mirek Giersz, Jongsuk Hong, Agostino Leveque, Abbas Askar, Diogo Belloni, M. Otulakowska-Hypka   +6 more
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Dentofacial Features in Schimke Immuno-Osseous Dysplasia: From Childhood to Adolescence. [PDF]

Clin Case Rep
Sharifinejad A, Parvizi F, Enteghad M, Ghahramani Y.   +3 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source