Results 31 to 40 of about 21,341,502 (280)

Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains [PDF]

, 2018
The α-synuclein protein, encoded by SNCA, has a key role in the pathogenesis of Parkinson's disease and other synucleinopathies. Although usually sporadic, Parkinson's disease can result from inherited copy number variants in SNCA and other genes.
Jan-Willem Taanman, Tammaryn Lashley, Helen Ling, Nacheva, E, Pease, Daniel, Lashley, Tammaryn, Katya Mokretar, Henry Houlden, Christos Proukakis, Mokretar, Katya, Schapira, AHV, Ling, Helen, Soenmez, A, Lashley, T, Schapira, Anthony HV, Proukakis, C, Ayesha Ejaz, Proukakis, Christos, Houlden, H, Anthony H V Schapira, Steve Gentleman, Soenmez, Aynur, Gentleman, Steve, Taanman, Jan-Willem, Janice L Holton, Gentleman, S, Pease, D, Ejaz, A, Ejaz, Ayesha, Holton, Janice L, Aynur Soenmez, Houlden, Henry, Nacheva, Elizabeth, Holton, JL, Elizabeth Nacheva, Taanman, J-W, Ling, H, Mokretar, K, Daniel Pease   +38 more
core   +1 more source

Pan-American Consortium of Multiple System Atrophy (PANMSA). A Pan-American multicentre cohort study of Multiple System Atrophy

Journal of Parkinson’s Disease, 2014
Background: Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.
Emilia Gatto, Mayela Rodríguez-Violante, Carlos Cosentino, Pedro Chana-Cuevas, Marcelo Miranda, Ellin Gallin, Jose L. Etcheverry, Yesenia Nuñez, Virginia Parisi, Gabriel Persi, Celeste Vecchi, Ana Sanguinetti, Alejandro Alleva, Juliana Aparcana, Luis Torres, Irene Litvan   +15 more
doaj   +1 more source

Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

Radiology Case Reports, 2023
We encountered a case of multiple system atrophy parkinsonian subtype (MSA-P) with right-dominant parkinsonism in the early stage of the disease. Atrophy of the posterolateral putamen and iron deposition are the neuropathological hallmark of MSA-P ...
Koichiro Mori, MD, Akira Yagishita, MD, Toshio Shimizu, MD, PhD   +2 more
doaj   +1 more source

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

, 2022
Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods.
Schoettker, P., Asboth, Leonie, Asboth, L., Berney, Maxime, Allenbach, G., Becce, F., Amir, Suje, Wuerzner, G., Bally, J.F., Paley, Aurelie, Demesmaeker, R., Courtine, G., Hankov, Nicolas, Jimenez, Mayte Castro, Paley, A., Hankov, N., Amir, S., Bally, Julien F., Courtine, Gregoire, Squair, J.W., Schoettker, Patrick, Becce, Fabio, Hernandez-Charpak, S., Squair, Jordan W., Dumont, Gregory, Allenbach, Gilles, Berney, M., Hernandez-Charpak, Sergio, Castro Jimenez, M., Demesmaeker, Robin, Bloch, J., Dumont, G., Bloch, Jocelyne, Wuerzner, Gregoire   +33 more
core   +1 more source

Quantification of cerebral tissue volumes in multiple sclerosis: global and regional analysis [PDF]

, 2006
Brain atrophy has been reported in multiple sclerosis (MS). We addressed the question of GM and WM tissue loss in a large population of 597 patients with multiple sclerosis (MS) compared with 104 control subjects using a fully automated, operator ...
Prinster, Anna
core   +1 more source

A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

Molecular Therapy: Nucleic Acids
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes.
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa   +13 more
doaj   +1 more source

Dystonia in multiple system atrophy [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2002
To delineate the frequency and nature of dystonia in multiple system atrophy (MSA).A cohort of 24 patients with clinically probable MSA over the past 10 years were prospectively followed up. Motor features were either dominated by parkinsonism (MSA-P subtype, n=18) or cerebellar ataxia (MSA-C, n=6). Classification of dystonic features and their changes
S M, Boesch, G K, Wenning, G, Ransmayr, W, Poewe   +3 more
openaire   +2 more sources

External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis

Neural Regeneration Research, 2023
Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations.
Massimiliano Todisco, Giuseppe Cosentino, Enrico Alfonsi   +2 more
doaj   +1 more source

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications

Neuroscience Research
Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD).
Norihito Uemura
doaj   +1 more source

Diagnosis of multiple system atrophy [PDF]

Autonomic Neuroscience, 2018
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease.
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann   +2 more
openaire   +2 more sources