Results 31 to 40 of about 216,096 (151)

Pan-American Consortium of Multiple System Atrophy (PANMSA). A Pan-American multicentre cohort study of Multiple System Atrophy

Journal of Parkinson’s Disease, 2014
Background: Multiple system atrophy (MSA) is an adult-onset and rapidly progressive, neurodegenerative condition that presents with autonomic dysfunction, parkinsonism, cerebellar ataxia and corticospinal deficits.
Emilia Gatto, Mayela Rodríguez-Violante, Carlos Cosentino, Pedro Chana-Cuevas, Marcelo Miranda, Ellin Gallin, Jose L. Etcheverry, Yesenia Nuñez, Virginia Parisi, Gabriel Persi, Celeste Vecchi, Ana Sanguinetti, Alejandro Alleva, Juliana Aparcana, Luis Torres, Irene Litvan   +15 more
doaj   +1 more source

Asymmetrical putaminal atrophy in parkinsonism-predominant multiple system atrophy (MSA-P): A case report

Radiology Case Reports, 2023
We encountered a case of multiple system atrophy parkinsonian subtype (MSA-P) with right-dominant parkinsonism in the early stage of the disease. Atrophy of the posterolateral putamen and iron deposition are the neuropathological hallmark of MSA-P ...
Koichiro Mori, MD, Akira Yagishita, MD, Toshio Shimizu, MD, PhD   +2 more
doaj   +1 more source

A lipid nanoparticle-based oligodendrocyte-specific mRNA therapy

Molecular Therapy: Nucleic Acids
Despite the wide range of applications of mRNA therapies, major difficulties exist in the efficient delivery of mRNA into oligodendrocytes, a type of glial cell in the brain. Commonly used viral vectors are not efficient in transforming oligodendrocytes.
Masanori Sawamura, Kiyoshi Tachikawa, Rie Hikawa, Hisako Akiyama, Seiji Kaji, Ken Yasuda, Angel I. Leu, Hyojung Hong, Rajesh Mukthavaram, Pad Chivukula, Hodaka Yamakado, Yoshio Hirabayashi, Ryosuke Takahashi, Shu-ichi Matsuzawa   +13 more
doaj   +1 more source

Diagnosis of multiple system atrophy [PDF]

Autonomic Neuroscience, 2018
Multiple system atrophy (MSA) may be difficult to distinguish clinically from other disorders, particularly in the early stages of the disease. An autonomic-only presentation can be indistinguishable from pure autonomic failure. Patients presenting with parkinsonism may be misdiagnosed as having Parkinson disease.
Jose-Alberto Palma, Lucy Norcliffe-Kaufmann, Horacio Kaufmann   +2 more
openaire   +2 more sources

External anal sphincter electromyography in multiple system atrophy: implications for diagnosis, clinical correlations, and novel insights into prognosis

Neural Regeneration Research, 2023
Multiple system atrophy is a sporadic, progressive, adult-onset, neurodegenerative disorder characterized by autonomic dysfunction symptoms, parkinsonian features, and cerebellar signs in various combinations.
Massimiliano Todisco, Giuseppe Cosentino, Enrico Alfonsi   +2 more
doaj   +1 more source

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications

Neuroscience Research
Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD).
Norihito Uemura
doaj   +1 more source

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source

Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

Acta Neuropathologica Communications, 2019
Synucleinopathies [Parkinson’s disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions.
Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson, Michel Goedert   +5 more
doaj   +1 more source

Cutaneous silent periods in multiple system atrophy

Biomedical Papers, 2015
Aim: The cutaneous silent period (CSP) is a spinal inhibitory reflex primarily mediated by A-delta fibers. Prolonged CSPs have been reported in patients with restless legs syndrome (RLS) and idiopathic Parkinson's disease (IPD).
Ivana Stetkarova, Markus Kofler, Veronika Majerova   +2 more
doaj   +1 more source

Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy.

PLoS ONE, 2019
Radiological biomarkers have been reported for multiple system atrophy and progressive supranuclear palsy, but serum/plasma biomarkers for each disorder have not been established.
Akio Mori, Kei-Ichi Ishikawa, Shinji Saiki, Taku Hatano, Yutaka Oji, Ayami Okuzumi, Motoki Fujimaki, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi, Nobutaka Hattori   +10 more
doaj   +1 more source