Results 41 to 50 of about 21,341,502 (280)

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source

Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

Acta Neuropathologica Communications, 2019
Synucleinopathies [Parkinson’s disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions.
Therése Klingstedt, Bernardino Ghetti, Janice L. Holton, Helen Ling, K. Peter R. Nilsson, Michel Goedert   +5 more
doaj   +1 more source

Cutaneous silent periods in multiple system atrophy

Biomedical Papers, 2015
Aim: The cutaneous silent period (CSP) is a spinal inhibitory reflex primarily mediated by A-delta fibers. Prolonged CSPs have been reported in patients with restless legs syndrome (RLS) and idiopathic Parkinson's disease (IPD).
Ivana Stetkarova, Markus Kofler, Veronika Majerova   +2 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Iron deficiency in parkinsonism : region-specific iron dysregulation in Parkinson's disease and multiple system atrophy [PDF]

Alpha synuclein pathology is widespread and found in diverse cell types in multiple system atrophy (MSA) as compared to Parkinson's disease (PD). The reason for this differential distribution is unknown.
Visanji, Naomi P., Finnegan, Mary E., Collingwood, Joanna F., Hazrati, Lili-Naz, Tandon, Anurag, House, Emily   +5 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A genome-wide association study in multiple system atrophy [PDF]

, 2016
OBJECTIVE: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS).
Wüllner, U, Hardy, JA, Albanese, A, Bhatia, Kailash P., Federoff, HJ, Federoff, Monica,, Ross, Owen A.,, CORTELLI, PIETRO, Albanese, A., Widner, H, Traynor, Bryan J, Revesz, Tamas, Ferrucci, L., Bloem, BR, Bhatia, K.P., Bloem, Bastiaan R., Schulte, Claudia, Meissner, W.G., Holton, J.L., Schottlaender, Lucia,, Poewe, W, Tolosa, Eduardo,, Bloem, Bastiaan R, Tolosa, Eduardo, Pellecchia, M.T., Dickson, Dennis W, Rascol, O, Schottlaender, L, Dickson, DW, Price, T Ryan, Mencacci, Niccolo E.,, Mhyre, Timothy R.,, Gasser, T, Dickson, Dennis W., Schottlaender, Lucia, Mhyre, TR, Hardy, John A.,, Revesz, T, the UK Multiple System Atrophy Study Group, Nalls, Michael A., Revesz, T., Lees, Andrew, ], Traynor, Bryan J.,, Ferrucci, Luigi, Houlden, H, Ferreira, Joaquim, Wood, Nicholas W., Traynor, Bryan J., Ling, Helen,, Infante, J., Mhyre, T.R., Oertel, Wolfgang, Wenning, Gregor K.,, Mencacci, NE, Bhatia, Kailash P.,, Mhyre, Timothy R., Rascol, Olivier, Gasser, Thomas, Mok, K, Ferreira, J., Quinn, Niall, Mok, K., Wullner, U., Federoff, M., Wüllner, Ullrich,, Höglinger, GU, Oertel, W, Ross, Owen A., Chelban, Viorica, Revesz, Tamas,, Pellecchia, MT, Wenning, Gregor K., Morris, H.R., O'Sullivan, SS, Mencacci, Niccolo E, Oertel, Wolfgang,, Höglinger, Günter U.,, Bhatia, KP, PELLECCHIA, MARIA TERESA, Ling, H, Widner, Hakan, Gasser, T., Federoff, Howard J.,, Nalls, M.A., Ling, H., Ferreira, Joaquim,, Goldwurm, Stefano, Singleton, Andrew B, Widner, Håkan,, Wood, NW, Ferreira, J, Mok, Kin, Singleton, Andrew B.,, Hardy, John A., Lees, Andrew,, Albanese, Alberto,, Meissner, Wassilios G.,, Gasser, Thomas,, O'Sullivan, Sean S., Morris, Huw R., European Multiple System Atrophy Study Group and the UK Multiple, Wüllner, Ullrich, Goldwurm, S., Sailer, A, Quinn, N, Holton, Janice L, Sailer, Anna,, Holton, JL, Wood, N.W., Bhatia, Kailash P, Ross, O.A., Meissner, Wassilios G., Schulte, C., Ferrucci, Luigi,, Federoff, M, Poewe, W., O'Sullivan, Sean S.,, Price, T. Ryan, Sailer, A., Höglinger, Günter U, Singleton, Andrew B., Widner, H., Chelban, V, Meissner, WG, Höglinger, Günter U., Rascol, Olivier,, Mencacci, N.E., Federoff, Monica, Price, T. Ryan,, Ferrucci, L, Deuschl, G., Scholz, Sonja W., Price, TR, Albanese, Alberto, Hoglinger, G.U., Poewe, Werner,, Scholz, SW, Traynor, BJ, Rascol, O., Lund University., Wood, Nicholas W, Nalls, Michael A.,, Nalls, MA, Pellecchia, Maria Teresa,, Ross, Owen A, Chelban, V., Ling, Helen, Calandra-Buonaura, Giovanna, Federoff, H.J., O'Sullivan, S.S, Scholz, Sonja W, Schottlaender, L., Tolosa, E., Scholz, S.W., Chelban, Viorica,, Wenning, G.K., Quinn, Niall,, Quinn, N., Infante, Jon, Wenning, Gregor K, Houlden, Henry,, Morris, Huw R, Houlden, Henry, Mok, Kin,, Lees, A., Deuschl, Günther,, Mencacci, Niccolo E., Holton, Janice L., Holton, Janice L.,, Tolosa, E, Morris, HR, Lees, A, Hardy, J.A., Infante, Jon,, Federoff, Howard J., Goldwurm, S, Nalls, Michael A, CALANDRA BUONAURA, GIOVANNA, Sailer, Anna, CAPELLARI, SABINA, Oertel, W., Poewe, Werner, Deuschl, G, Scholz, Sonja W.,, Singleton, AB, Meissner, Wassilios G, Schulte, Claudia,, Traynor, B.J., Goldwurm, Stefano,, Infante, J, Singleton, A.B., Hardy, John A, Schulte, C, Ross, OA, Bloem, B.R., Bloem, Bastiaan R.,, European Multiple System Atrophy Study Group [, Deuschl, Günther, Dickson, D.W., Mhyre, Timothy R, Morris, Huw R.,, Dickson, Dennis W.,, Wenning, GK, Houlden, H., Price, T.R., O'Sullivan, Sean S, Wood, Nicholas W.,, Federoff, Howard J   +208 more
core   +2 more sources

Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy.

PLoS ONE, 2019
Radiological biomarkers have been reported for multiple system atrophy and progressive supranuclear palsy, but serum/plasma biomarkers for each disorder have not been established.
Akio Mori, Kei-Ichi Ishikawa, Shinji Saiki, Taku Hatano, Yutaka Oji, Ayami Okuzumi, Motoki Fujimaki, Takahiro Koinuma, Shin-Ichi Ueno, Yoko Imamichi, Nobutaka Hattori   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Heredity in multiple system atrophy [PDF]

Journal of the Neurological Sciences, 2006
We investigated the family histories of 157 Japanese patients with probable or possible multiple system atrophy (MSA). A family history of neurodegenerative disorders was only detected in three MSA patients (1.9%). We evaluated these patients by careful neurological examination, neuroimaging studies, and genetic studies to exclude hereditary ...
Soma, Hiroyuki, Yabe, Ichiro, Takei, Asako, Fujiki, Naoto, Yanagihara, Tetsuro, Sasaki, Hidenao   +5 more
openaire   +4 more sources