Results 131 to 140 of about 2,232,801 (311)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Testing for complementarity and substitutability in case of multiple practices
A number of recent empirical studies of firm-level productivity (growth) have been concerned with establishing potential complementarity between multiple organizational design practices.
Lokshin,Boris +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
False discovery rate-controlled multiple testing for union null hypotheses: a knockoff-based approach. [PDF]
Biometrics, 2023 Dai R, Zheng C.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Nonmanipulable Bayesian Testing [PDF]
This paper considers the problem of testing an expert who makes probabilistic forecasts about the outcomes of a stochastic process. I show that, under general conditions on the tester's prior, a likelihood test can distinguish informed from uninformed ...
Colin Stewart
core
Multiple controlled random testing
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 Various methods for generating controlled random tests and their disadvantages are considered. Various numerical metrics are proposed and analyzed to construct multiple controlled random tests. The effectiveness of applying the Euclidean distance for the
V. A. Levantsevich, V. N. Yarmolik
doaj
TEAM: A MULTIPLE TESTING ALGORITHM ON THE AGGREGATION TREE FOR FLOW CYTOMETRY ANALYSIS. [PDF]
Ann Appl Stat, 2023 Pura JA, Li X, Chan C, Xie J.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Testing of a Structures Covariance Matrix for Three-Level Repeated Measures Data. [PDF]
This paper considers the problem of estimating, and testing for, a Kronecker product covariance structure of three-level (multiple time points (p), multiple sites (u), and multiple response variables (q)) multivariate data.
Ricardo Leiva, Anuradha Roy
core