Results 101 to 110 of about 27,174,491 (303)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Multiple time scales in modeling the incidence of infections acquired in intensive care units [PDF]

, 2016
Background When patients are admitted to an intensive care unit (ICU) their risk of getting an infection will be highly depend on the length of stay at-risk in the ICU.
Olaechea-Astigarraga, P, Palomar-Martinez, M, Barnett, AG, Wolkewitz, M., Ben S. Cooper, Palomar Martínez, Mercedes, Wolkewitz, Martin, Alvarez-Lerma, Francisco, Pedro Olaechea-Astigarraga, Francisco Alvarez-Lerma, Cooper, Ben S., Barnett, Adrian G., Cooper, Ben, Schumacher, Martin, Álvarez Lerma, Francisco, Mercedes Palomar-Martinez, Adrian G. Barnett, Wolkewitz, M, Martin Schumacher, Palomar-Martinez, Mercedes, Schumacher, M, Martin Wolkewitz, Universitat Autònoma de Barcelona, Olaechea-Astigarraga, Pedro, Alvarez-Lerma, F, Olaechea-Astigarraga, P.   +25 more
core   +3 more sources

Identifying Ordinal Similarities at Different Temporal Scales

Entropy
This study implements the permutation Jensen–Shannon distance as a metric for discerning ordinal patterns and similarities across multiple temporal scales in time series data.
Luciano Zunino, Xavier Porte, Miguel C. Soriano   +2 more
doaj   +1 more source

ON HMM-like integrators and projective integration methods for systems with multiple time scales [PDF]

Communications in Mathematical Sciences, 2007
HMM-like multiscale integrators and projective integration methods are two different types of multiscale integrators which have been introduced to simulate efficiently systems with widely disparate time scales. The original philosophies of these methods, reviewed here, were quite different. Recently, however, projective integration methods seem to have
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

An iterative method for faster sum-of-pairs multiple sequence alignment [PDF]

, 2000
Reinert K, Stoye J, Will T. An iterative method for faster sum-of-pairs multiple sequence alignment. Bioinformatics.
Stoye, Jens ; https://orcid.org/, Reinert, Knut, Will, Torsten   +2 more
core   +1 more source

A time-parallel multiple-shooting method for large-scale quantum optimal control

Journal of Computational Physics
Quantum optimal control plays a crucial role in quantum computing by providing the interface between compiler and hardware. Solving the optimal control problem is particularly challenging for multi-qubit gates, due to the exponential growth in computational complexity with the system's dimensionality and the deterioration of optimization convergence ...
N. Anders Petersson, Stefanie Günther, Seung Whan Chung   +2 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A New Approach for Studying Nonlinear Dynamic Response of a Thin Plate with Internal Resonance in a Fractional Viscoelastic Medium

Shock and Vibration, 2015
In the previous analysis, the dynamic behaviour of a nonlinear plate embedded into a fractional derivative viscoelastic medium has been studied by the method of multiple time scales under the conditions of the internal resonances two-to-one and one-to ...
Yury A. Rossikhin, Marina V. Shitikova, Jean Claude Ngenzi   +2 more
doaj   +1 more source