Results 241 to 250 of about 281,013 (338)

AmpliconTyper - a tool for analysing ONT multiplex PCR data from environmental and other complex samples. [PDF]

Microb Genom
Spadar A, Mahindroo J, Troman C, Owusu M, Adu-Sarkodie Y, Owusu-Dabo E, Abraham D, Benny B, Govindan K, Mohan VR, Dyson ZA, Grassly N, Holt KE.   +12 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Impact of multiplex PCR respiratory viral panel testing on antibiotic utilisation in children with acute febrile and respiratory illnesses. [PDF]

BMJ Paediatr Open
Bhaskaran PN, Moni M, T Sathyapalan DT, Jose S, Krishna A, Rose L, Sudheer A, Kishore K, Menon V.   +8 more
europepmc   +1 more source

Development of a Multiplex PCR Test with Automated Genotyping Targeting E7 for Detection of Six High-Risk Human Papillomaviruses

, 2015
Eliana Ferreira Paes, Ângela Maria de Assis, Cirbia Silva Campos Teixeira, Francisco Hideo Aoki, Júlio César Teixeira   +4 more
openalex   +2 more sources

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Comparative evaluation of enteric bacterial culture and a molecular multiplex syndromic panel in children with acute gastroenteritis [PDF]

, 2019
Alberta Provincial Pediatric EnTeric Infection TEam (APPETITE),, Berenger, Byron M, Burnham, Carey-Ann D, Chui, Linda, Freedman, Stephen B, Kellner, Thomas, Lee, Bonita E, Nettel-Aguirre, Alberto, Pang, Xiao-Li, Parsons, Brandon, Szelewicki, Jonas, Tarr, Phillip I, Vanderkooi, Otto G, Xie, Jianling, Zelyas, Nathan   +14 more
core   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Prevalence of six respiratory pathogens among children in Chengdu, China: a multiplex PCR-based detection study. [PDF]

Front Cell Infect Microbiol
Liu C, Li J, Deng Y, Wang Q, Wang X, Yang S, He W, Liao Z.   +7 more
europepmc   +1 more source

Detection of Some SalmonellaEnteritidisVirulence Genes by Multiplex-PCR Assay Using Two Different DNA Extraction Methods

, 2017
Kareem Thamir Al-Kaaby, Ahmed H. Al-Dabhaw, Hayder M. Samaka   +2 more
openalex   +2 more sources

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source