Results 111 to 120 of about 877,269 (241)

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

qRT-PCR validation of DEGs involved in tryptophan biosynthesis.

, 2019
qRT-PCR validation of DEGs involved in tryptophan biosynthesis.
Shuju Ning (5484932), Xiaogui Gong (6453707), Wei Huang (36889), Daozhi Wei (5484926), Wenjin Lin (5484929), Qi Ye (243032)   +5 more
core   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

qRT-PCR validation for 9 candidate transcripts.

, 2017
Log2FC means log2 fold change in RNA-Seq experiment while RNE means relative normalized expression (2-ΔΔCt) in qRT-PCR experiment. Error bar represents the standard deviation.
Jianhua Miao (3530219), Changming Mo (3611324), Longhua Bai (3530222), Shugen Wei (3611318), Zhonglian Zhang (3611321), Hao Huang (111923), Limei Pan (3611330), Jine Fu (3611333), Yanhong Guan (3611327), Xiaojun Ma (231882), Maoshan Chen (194424)   +10 more
core   +1 more source

Predominance of arboviruses in acute encephalitis and Guillain–Barré syndrome: Findings from a prospective cohort in Northeast Brazil

International Journal of Infectious Diseases
Objectives: To characterize the clinical, epidemiological, and laboratory spectrum of acute viral-associated neurological syndromes in an arbovirus-endemic region of northeastern Brazil.
Mateus Santana do Rosário, Maria Paula de Souza Sampaio, Lorena Cunha Martins, Luiza Vieira Luedy Trindade, Gabriela Farias Carreiro, Breno Pinheiro de Almeida Franco e Castro, Bernardo Gratival Gouvea Costa, Gessica Almeida Vasconcelos, Jesângeli de Souza Dias, Alan Oliveira Duarte, Fernanda Lopes Habib, Cassia Flavia Moreira Souza, Pedro Sampaio Almeida Ramos Conceição, Mariellen Santos de Jesus Souza, Pedro Antonio Pereira de Jesus, Daniel Santana Farias, Murilo Santos Souza, Adilson Junior Pinto Galvão, Felipe Oliveira Costa, Tarsis Leonardo Almeida Farias, Jamary Oliveira Filho, Thiago Gonçalves Fukuda, Celia Silvany, Janeusa Rita Leite Primo Chagas, Jose Mário Meira Teles, Gubio Soares Campos, Silvia Inês Sardi, Ively Paixão Santos, Ricardo Khouri, Marcia Carvalho Bessa, Maricelia Maia de Lima, Tiago Gräf, Isadora Cristina de Siqueira   +32 more
doaj   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Primer and probe sequences for qRT-PCR

, 2016
Primer and probe sequences for qRT ...
Helena J. Maier (3043422), Mark Fife (3043425), Ambalika Batra (3043431), William Mwangi (3043428), Colin Butter (104550), John R. Young (104544), Karen Staines (104539), Steven Van Borm (313768)   +7 more
core   +1 more source

Molecular Detection of Type II Toxin RelE Gene and Relation with Biofilm Formation in Escherichia Coli

Ibn Al-Haitham Journal for Pure and Applied Sciences
Escherichia coli is the principal etiological agent of urinary tract infections (UTIs) and exhibits significant antibiotic resistance, driven by various virulence factors. Fifty E.
Areej Jasem Mohammad, Enass Ghassan Sweedan   +1 more
doaj   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

qRT-PCR primer sequence information used in this study.

, 2018
qRT-PCR primer sequence information used in this study.
Johan J. van Vuren (5848178), Yared B. Yohannes (5848175), Victor Wepener (5848181), Shouta M. M. Nakayama (821932), Wageh S. Darwish (5848172), Ahmed Tharwat (5848190), Lesa A. Thompson (5848169), Nico J. Smit (5848184), Hazuki Mizukawa (821933), Atnafu G. Assefa (5848187), Walaa Fathy Saad Eldin (5848193), Yoshinori Ikenaka (464562), Mayumi Ishizuka (264469)   +12 more
core   +1 more source