Results 51 to 60 of about 296,891 (323)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Dermatology Online Journal, 2003 A 25-year-old man with a 20-year history of asymptomatic nodules on his arms and trunk, which histopathological analysis showed to be consistent with steatocystoma multiplex, is presented. Steatocystoma multiplex is a disorder characterized by multiple, asymptomatic, dermal cysts that usually occur on the trunk and proximal aspects of the extremities ...
openaire +4 more sources
Multiplexity and multireciprocity in directed multiplexes
Physical Review E, 2016 20 pages, 8 ...
Gemmetto, V. +4 more
openaire +6 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
A Parallelized Nanofluidic Device for High-Throughput Optical DNA Mapping of Bacterial Plasmids
Micromachines, 2021 Optical DNA mapping (ODM) has developed into an important technique for DNA analysis, where single DNA molecules are sequence-specifically labeled and stretched, for example, in nanofluidic channels.
Sriram KK +6 more
doaj +1 more source
Diversity versus Multiplexing at Finite Blocklength
, 2014 A finite blocklenth analysis of the diversity-multiplexing tradeoff is presented, based on nonasymptotic bounds on the maximum channel coding rate of multiple-antenna block-memoryless Rayleigh-fading channels.The bounds in this paper allow one to ...
Durisi, Giuseppe +3 more
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Acquisition of Neural Action Potentials Using Rapid Multiplexing Directly at the Electrodes
Micromachines, 2018 Neural recording systems that interface with implanted microelectrodes are used extensively in experimental neuroscience and neural engineering research.
Mohit Sharma +5 more
doaj +1 more source
Compendium of Plant-Specific CRISPR Vectors and Their Technical Advantages
Life, 2021 CRISPR/Cas mediated genome editing is a revolutionary approach for manipulating the plant genome. However, the success of this technology is highly dependent on selection of a specific vector and the other components.
Anshu Alok +5 more
doaj +1 more source