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Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
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TREX1, a predator for treating MSI‐H tumors?
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Correlations between multiplicities in rapidity and azimuthally separated windows
V. Vechernin
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Multiple multiple-exposure hologram
Applied Optics, 1985The number of holograms that can be linearly superimposed on one photographic plate has two fundamental limits; one is the finite extent of the characteristic amplitude transmittance vs energy-of-exposure (Ta − E) film curve, and the other is holographic reciprocity law failure [ K. M. Johnson L. Hesselink J. W. Goodman , Appl.
K M, Johnson +3 more
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Medicine, 2000
Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transient and remyelination occurs but is not durable. Hence, the early course of disease is characterised by episodes of neurological dysfunction that usually ...
Alastair, Compston, Alasdair, Coles
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Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transient and remyelination occurs but is not durable. Hence, the early course of disease is characterised by episodes of neurological dysfunction that usually ...
Alastair, Compston, Alasdair, Coles
openaire +3 more sources
Multiple Authors, Multiple Problems
Science, 2003T he average number of authors on scientific papers is skyrocketing. That's partly because labs are bigger, problems are more complicated, and more different subspecialties are needed. But it's also because U.S. government agencies like the National Institutes of Health (NIH) have started to promote “team science.” As physics developed in the post ...
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Multiplicity 2: Multiple treatments and multiple outcomes
American Journal of Orthodontics and Dentofacial Orthopedics, 2013CB, Conventional brackets; pSLB, passive self-ligating brackets; aSLB, active self-ligating brackets. In the previous article, I discussed subgroup analyses. In this article and the next, we will consider other aspects of clinical trials that lead to multiplicity of data when multiple hypotheses are tested at the same time.
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Multiple operand addition and multiplication
Proceedings of the December 5-7, 1972, fall joint computer conference, part I on - AFIPS '72 (Fall, part I), 1972zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Singh, Shanker, Waxman, Ronald
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Multiple Gestations: Multiple Headaches
2016Twins now comprise over 3 % of all live births in the USA. This incidence has increased over the years, mainly due to the expanding use of assisted reproductive technologies. Twins may be monozygotic (one egg, fertilized by one sperm cell) or dizygotic (two eggs, fertilized by two sperm cells).
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