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Results 91 to 100 of about 5,636 (282)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source

NIETZSCHE. PHILOSOPHER OF MULTIPLICITY AND THE MASK

, 1986
MULTIPLICITY IS SEEN, WITHIN THE FRAMEWORK OF OUR PARTICULAR APPROACH IN DIFFERENT PERSPECTIVE. INDEED THE GENERALLY ACCEPTED INTERPRETATION OF NIETZCHE (GARNIER, HEIDEGGER, JASPERS, KAUFMANN) REFERS ON THE ONE HAND TO THE FACT THAT HE IS PRESENTING A
Λαμπρέλλης, Δημήτριος
core +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source

Unity Before Multiplicity: Individuation as a Structural Constraint on Grounding

Recent metaphysical debates have increasingly shifted from questions of existence to questions of ontological priority and dependence, often articulated in terms of grounding relations.
Rivera, Miguel Ángel
core +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source

Mandala – a symbol of the reflection of unity in multiplicity. The interpretation of this motif in contemporary art

, 2017
The mandala symbol, which is a sui generis cultural phenomenon, however not because of its uniqueness, but generality of occurrence, and also a subject of the author's research interests, became the reason for writing this article. Mandala in the Eastern
Gil, Anna
core

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source

A unity of the self or a multiplicity of locations? How the graphesthesia task sheds light on the role of spatial perspectives in bodily self-consciousness

, 2017
Integrating multisensory stimuli from a self-centred perspective is crucial for the unity of the self. On the other hand, understanding external space and communicating spatial knowledge with others necessitate the adoption of decentred perspectives. How
Auvray, M +8 more
core +1 more source

Multiplicity dependence of K*(892) ±  production in pp collisions at s=13 TeV

Physics Letters B
The first results of K*(892) ±  production at midrapidity (|y| 
I.J. Abualrob +1067 more
doaj +1 more source

multiplicity
unity
unity of existence

one
mulla sadra
unity in multiplicity

individual unity of existence
identity
mysticism