Results 111 to 120 of about 114,760,913 (293)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

UNITY Post-Meeting Letter

, 1989
Letter from UNITY to Fr. Locatelli which states the three demands that UNITY presented to Fr. Locatelli at their meeting held on Friday, April 14, 1989 and says that, should Locatelli "deny the demands," that "UNITY will "withdraw and withhold ethnic ...
Gonzalves, Rutherford S.
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

General equilibrium, coordination and multiplicity on spot markets [PDF]

This is a slightly revised English version of a paper published in the "Revue d'Economie Politique" 112 (5) sept-oct 2002. The text reviews recent work on expectational coordination in general equilibrium models of the Walrasian tradition.
Roger Guesnerie
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Presentation at the Fifth Ordinary Session of the Council of Ministers of the various recommendations submitted by the Organization of African Unity Specialised Commissions concerning their studies of the various aspects of the elements of African Unity bearing in mind Ghana's proposal aiming at the "Establishment of a Union Government of Africa"

, 1965
Council of Ministers, Fifth Ordinary Session, Accra, October 1965Study and proposal of the Organization of African Unity Specialized Commissions to the Council of Ministers on the various aspects of the elements of African Unity, including solidarity ...
Organization of African Unity
core   +1 more source

Nietzsche and the Methodological Fictions: from Logical Unity to Methodological Pluralism

Sententiae
The paper offers a systematic interpretation of Friedrich Nietzsche’s reflections on language and logic by arguing that they function as methodological fictions grounded in a psychophysiological account of cognition. It first shows that Nietzsche’s early
Márcio José Silveira Lima
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Alkalmazásfejlesztés Unity Engine-nel

, 2017
A szakdolgozatban egy Tower Defense típusú játékot készítettem el a Unity játékmotor segítségével. Bemutatom a Unity kezelőfelületét, a játék főbb komponenseit és ismertetek néhány kódolási szokást.BSc/BAProgramtervező ...
Oros, Tibor
core