Results 121 to 130 of about 5,636 (282)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Conscious Unity from the Top Down: A Brentanian Approach [PDF]
, 2017 The question of the unity of consciousness is often treated as the question of how different conscious experiences are related to each other in order to be unified.
Giustina, Anna
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Non-Euclidean transformations: multiplicity in a contemporary art jewellery practice
, 2016 Non-Euclidean transformations is a practice-based PhD research project that investigates multiplicity and unity within a series of artworks that explore the idea of a spatial temporal continuum.
Helen Dilkes (20097423)
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Nietzsche and the Methodological Fictions: from Logical Unity to Methodological Pluralism
SententiaeThe paper offers a systematic interpretation of Friedrich Nietzsche’s reflections on language and logic by arguing that they function as methodological fictions grounded in a psychophysiological account of cognition. It first shows that Nietzsche’s early
Márcio José Silveira Lima
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
*I am turning this dissertation into a monograph. Please contact me if you will cite it. Comments and questions are welcome!* Abstract: This dissertation discusses al-Fārābī’s views on unity presented in his Kitāb al-wāḥid ...
Genc, Hakan
core
Unity in Number in Al-Fārābī’s Kitāb al-Wāḥid wa-l-Waḥda (Book of the One and Unity)
Al-Fārābī’s discussion of the senses of unity in Kitab al-Wāḥid wa-l-Waḥda (Book of the One and Unity) (henceforth KW) has its origin mainly in Aristotle’s discussion of the senses of unity and multiplicity in Metaphysics Delta 6 and Iota, but there are ...
Genc, Hakan
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source