Results 51 to 60 of about 5,144 (214)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Specifics of Project Management on Industrial Innovation

Proceedings of the International Conference on Applied Innovations in IT, 2018
The paper offers a scientific and methodological approach to assessing the efficiency of innovative projects which develops and supplements the theoretical bases of innovative projects analysis through the accounting of recursive dependence of ...
Stepan Mezhov, Leonid Mylnikov
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Multiplier effect of the new mechanism for forming regional policy for tourism industry development based on the program-project approach (the Vladimir Region case)

Вестник университета
Today, additional adjustment and optimization of state tourism development programs are required due to the multiplicative effects of tourism in other sectors of economy. Practice-oriented recommendations have been developed for forming the state program
I. I. Deren, D. Zemlyanikina
doaj   +1 more source

Design and Implementation of a New Frequency Synthesizer for Rubidium Atomic Frequency Standard

Chinese Journal of Magnetic Resonance, 2017
Progresses have been made in the development of digitalized and miniaturized rubidium atomic frequency standard (RAFS). In the traditional RAFS circuits, the 6 840 MHz microwave signal is mixed with the 5.312 5 MHz signal generated by the frequency ...
HUANG Zheng, YAN Shi-dong, MEI Gang-hua, ZHONG Da   +3 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

The empirical analysis of project effects of public works under deflation

Journal of Human Environmental Studies, 2012
In this paper, a theoretical hypothesis that public works would have deterrence effects of deflation under the situation that deflation-gap exists was tested empirically.
Satoshi Fujii, Keita Shibayama, Nakano Takeshi   +2 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Inversion and characterization of some potentials with the densities in lp in the non-elliptic case

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
We construct the inversion of generalized Strichartz potentials with singularities of the kernels on a finite union of spheres in Rn with densities from space Lp, 1≤p≤2 and Hardy space H1 in the non-elliptic case, when its symbols degenerate on a set of ...
Alexey V Gil, Anatoliy I Zadorozhnyi, Vladimir A Nogin   +2 more
doaj