Results 61 to 70 of about 485,720 (278)
Theory of J. M. Keynes as a revolutionary approach to economics.
In 2016 been celebrated the 80th anniversary of publication of the work of Keynes’ «General Theory of Employment, Interest and Money». This date are updated by exploration of the phenomenon of labor, forces to search for the answer to the question about ...
B. Z. Nurmanova
doaj
Aggressive prostate cancer is associated with pericyte dysfunction
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
An extension of Helson-Edwards theorem to Banach Modules
An extension of the Helson-Edwards theorem for the group algebras to Banach modules over commutative Banach algebras is given. This extension can be viewed as a generalization of Liu-Rooij-Wang's result for Banach modules over the group algebras.
Sin-Ei Takahasi
doaj +1 more source
Experimental demonstrations of quantum annealing with “native” implementation of Boolean logic Hamiltonians are reported. As a superconducting integrated circuit, a problem Hamiltonian whose set of ground states is consistent with a given ...
Daisuke Saida +6 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
FPGA-Based Multi-Level Approximate Multipliers for High-Performance Error-Resilient Applications
This paper presents approximate multipliers which are efficiently deployed on Field Programmable Gate Arrays (FPGAs) by using newly proposed approximate logic compressors at different levels of accuracy.
Nguyen Van Toan, Jeong-Gun Lee
doaj +1 more source
A smooth, complex generalization of the Hobby-Rice theorem
The Hobby-Rice Theorem states that, given $n$ functions $f_j$ on ${\mathbb{R}}^N$, there exists a multiplier $h$ such that the integrals of $f_jh$ are all simultaneously zero. This multiplier takes values~$\pm1$ and is discontinuous.
Lazarev, Oleg, Lieb, Elliott H.
core +1 more source
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source

