Results 61 to 70 of about 61,024 (262)

Polyomavirus T Antigens: Molecular Chaperones for Multiprotein Complexes [PDF]

Journal of Virology, 1998
Simian virus 40 (SV40) and murine polyomavirus (PyV) serve as powerful tools to identify key cellular regulatory proteins and to discern the mechanisms by which these proteins exert their biological effects. Like all members of the polyomavirus group, SV40 and PyV have simple genomes (Fig.
J L, Brodsky, J M, Pipas
openaire   +2 more sources

Controlling pre-leukemic thymocyte self-renewal [PDF]

, 2014
Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric
Goossens, Steven, Van Vlierberghe, Pieter   +1 more
core   +6 more sources

Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC)

Cells, 2013
Contemporary quantitative mass spectrometry provides fascinating opportunities in defining the stoichiometry of high-molecular weight complexes or multiprotein platforms.
Inna Lavrik, Uwe Warnken, Kolja Schleich, Martina Schnölzer   +3 more
doaj   +1 more source

ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts [PDF]

, 2016
Multicomponent biological systems perform a wide variety of functions and are crucially important for a broad range of critical health and disease states.
A Basters, A Kriz, AB Rode, AJ Jakobi, B Geering, B Weiss, BM Olivera, C Bieniossek, C Bieniossek, C Romier, C Schaffitzel, CP Chou, CV Robinson, D Busso, D Sari, D Schelshorn, DG Gibson, DJ Pitera, DN Gopaul, F Guo, F Leinert, G Bartani, G Gosset, G Kellenberger, H Alper, H Ye, HO Smith, J Komar, J Quan, J Torella, JA Chemler, JH Park, K Ballmer-Hofer, KB Mullis, LF Estrozi, LR Jarboe, LS Vijayachandran, M Folcher, M Gellert, M Haffke, M Haffke, M Meselson, MCY Chang, ML Diebold, ML Gefter, MZ Li, N Zheng, NR Cozzarelli, O Loeffelholz Von, PE Nisson, PJA Cock, R Patnaik, R Vincentelli, RJ Schulze, S Ausländer, S Cunna, S Linn, S Trowitzsch, S Trowitzsch, SC Almo, SE Luria, SJ Berríos-Rivera, SK Lee, SY Lee, T Maniatis, TC Terwilliger, VC Bode, W Abdulrahman, W Weber, WW Metcalf, Y Nie, Y Zhang   +71 more
core   +3 more sources

A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]

, 2005
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Štěpánka Vaňáčová, Jeannette Wolf, Georges Martin, Diana Blank, Sabine Dettwiler, Arno Friedlein, Hanno Langen, Gérard Keith, Walter Keller, Phillip Zamore, Wahle, Minvielle-Sebastia, Zhao, Edmonds, Proudfoot, Zorio, Aravind, Holm, Martin, Preker, Martin, Martin, Bard, Read, Saitoh, Wang, Sadoff, Wang, Wang, Crittenden, Kwak, Keller, van Hoof, Kuai, Kadaba, Mitchell, O'Hara, Li, Cheng, Dreyfus, Inoue, Martin, Puig, Lingner, de la Cruz, Wang, Vijayraghavan, Anderson, Gerber, Dirheimer, Mitchell, Walowsky, Dannull, Amarasinghe, Castaño, Basavappa, Kushner, Symmons, Parker, Torchet, Fromont-Racine, Ohnacker, Dichtl, Fountoulakis, Wilm, Dirheimer, Keith, Senger, Dichtl, Christofori, Falquet, Rain   +71 more
core   +4 more sources

Multiprotein Expression Strategy for Structural Biology of Eukaryotic Complexes [PDF]

Structure, 2007
The concept of the cell as a collection of multisubunit protein machines is emerging as a cornerstone of modern biology, and molecular-level study of these machines in most cases will require recombinant production. Here, we present and validate a strategy to rapidly produce, permutate, and posttranslationally modify large, eukaryotic multiprotein ...
Fitzgerald, Daniel J, Schaffitzel, Christiane, Berger, Philipp, Wellinger, Ralf, Bieniossek, Christoph, Richmond, Timothy J, Berger, Imre   +6 more
openaire   +4 more sources

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]

, 2016
The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H., Machesky, Laura M., Spence, Heather J., Strathdee, Douglas, Tyrrell, Benjamin J., Woodham, Emma F.   +5 more
core   +1 more source

Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. [PDF]

, 2016
Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX. It is hypothesized that either SS18-SSX disrupts SWI/SNF complex inhibition of the polycomb complex 2 (PRC2) methyltransferase Enhancer of Zeste ...
Choy, Edwin, Cote, Gregory M, Duan, Zhenfeng, Gao, Yan, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K   +6 more
core   +2 more sources

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Design and evaluation of a tripartite chemogenetic fluorescent reporter for visualizing ternary protein complexes

Nature Communications
Most cellular processes are carried out by multiprotein assemblies. Although various molecular tools exist to visualize binary protein interactions in live cells, the visualization of multiprotein complexes remains a challenge.
Sara Bottone, Fanny Broch, Antoine Gedeon, Aurélien Brion, Lina El Hajji, Hela Benaissa, Arnaud Gautier   +6 more
doaj   +1 more source