Results 121 to 130 of about 34,376 (260)

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Combination of plant metabolites hinders starch digestion and glucose absorption while facilitating insulin sensitivity to diabetes

Frontiers in Pharmacology
IntroductionDiabetes mellitus (DM) is a common endocrine disease resulting from interactions between genetic and environmental factors. Type II DM (T2DM) accounts for approximately 90% of all DM cases.
Xin Huang, Xin Huang, Kaihuang Lin, Kaihuang Lin, Sinian Liu, Sinian Liu, Junxiong Yang, Junxiong Yang, Haowei Zhao, Haowei Zhao, Xiao-Hui Zheng, Xiao-Hui Zheng, May-Jywan Tsai, Chun-Sheng Chang, Liyue Huang, Liyue Huang, Ching-Feng Weng, Ching-Feng Weng   +17 more
doaj   +1 more source

Multitarget tracking via restless bandit marginal productivity indices and Kalman Filter in discrete time [PDF]

This paper designs, evaluates, and tests a tractable priority-index policy for scheduling target updates in a discrete-time multitarget tracking model, which aims to be close to optimal relative to a discounted or average performance objective accounting
José Niño-Mora, Sofía S. Villar
core  

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Design, Synthesis, and Evaluation of Coumarin‐Rasagiline Hybrids as Multifunctional Neuroprotective Agents

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
Novel coumarin‐rasagiline hybrid molecules were designed and synthesized as multifunctional agents targeting key pathological mechanisms of neurodegenerative diseases. These compounds exhibited hMAO‐B inhibitory activity, antioxidant and neuroprotective effects, supported by ADMET profiling and molecular modeling studies. The design of hybrid molecules
Aitor Carneiro, Sandra Barreiro, Claudia Sofia Machado, Miguel Pinto, Daniel Chavarria, Manuel Novás, Davide Crucitti, Carlos Fernandes, Maria João Matos   +8 more
wiley   +1 more source

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Combined inhibition of atrial‐specific potassium currents as a possible anti‐arrhythmic drug therapy: A match made in silico

The Journal of Physiology, EarlyView.
Vladimír Sobota
wiley   +1 more source

The Cuttlebone Blueprint for Multifunctional Metamaterials: Design Taxonomy, Functional Decoupling, and Future Horizons

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Cuttlebone‐inspired metamaterials exploit a septum‐wall architecture to achieve excellent mechanical and functional properties. This review classifies existing designs into direct biomimetic, honeycomb‐type, and strut‐type architectures, summarizes governing design principles, and presents a decoupled design framework for interpreting multiphysical ...
Xinwei Li, Zhendong Li
wiley   +1 more source

Integrating Social Grouping for Multitarget Tracking Across Cameras in a CRF Model [PDF]

, 2017
Bhanu, Bir, Chen, Xiaojing
core   +1 more source

Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate

, 2017
Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and production of viral particles.
Cervantes-Pérez, Ángel, Ávila-Vales, Eric   +1 more
core