Results 141 to 150 of about 34,376 (260)

Escin Attenuates Amyloid Beta 1‐42‐Induced Oxidative Stress, Apoptosis, and Neuroinflammation in Neuron‐Like SH‐SY5Y Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
This study demonstrates that Escin pretreatment exerts potent neuroprotection against Aβ1‐42‐induced toxicity in differentiated SH‐SY5Y cells. By suppressing the NF‐κB inflammatory axis, mitigating oxidative stress, and inhibiting the apoptotic cascade, Escin provides a mechanistic basis for its potential as a therapeutic candidate for Alzheimer's ...
Sakine Akar, Ozge Alvur, Gulsah Evyapan, Berna Ozdem, Ilknur Porsuk Doru   +4 more
wiley   +1 more source

The Small Molecule H89 Facilitates Mesenchymal Stem Cell‐derived Extracellular Vesicle Release and Optimizes Therapeutic Efficacy in Liver Regeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT The role of human umbilical cord mesenchymal stem cell‐derived extracellular vesicles (hUCMSC‐EVs) in liver regeneration is promising, yet their clinical translation is hampered by insufficient production. Current strategies targeting their secretion are inefficient and lack a clear mechanistic understanding.
Yu Fu, Yi Ma, Jiajun Zhang, Liwei Liang, Ting Li, Zeyi Guo, Zhongzhe Li, Lei Feng, Yi Wang, Guolin He, Shao Li, Yang Li, Xiaoping Xu, Hui Liao, Yi Gao   +14 more
wiley   +1 more source

Whole‐Genome Bisulfite Sequencing Identifies Blood‐Based DNA Methylation Biomarker for Hepatocellular Carcinoma

Molecular Carcinogenesis, Volume 65, Issue 5, Page 603-614, May 2026.
ABSTRACT Functional DNA methylation abnormalities are a hallmark of human cancers and may be a promising biomarker for their early diagnosis. Moreover, the largest methylation differences can improve the sensitivity of noninvasive diagnoses of solid tumors.
Junsheng Zhao, Sijia Shen, Junjie Zhang, Ying Xu, Jing Peng, Hainv Gao, Lanjuan Li   +6 more
wiley   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 5, May 2026.
We systematically summarized the etiologies, diagnostic approaches, and pathogenic mechanisms of liver fibrosis. Also, the therapeutic interventions for liver fibrosis were systematically classified into two main categories: etiological treatment and mechanism‐based antifibrotic therapies.
Jiaorong Qu, Wenqing Qin, Minghang Dong, Zhi Ma, Si Li, Runping Liu, Ranyun Chen, Changmeng Li, Xiaojiaoyang Li   +8 more
wiley   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates. [PDF]

Pharmaceuticals (Basel)
Lima ADS, Lima LM.
europepmc   +1 more source

ConGen: Targeted Molecule Generation Through Contrastive Learning and Latent Optimization

Molecular Informatics, Volume 45, Issue 5, May 2026.
We present ConGen, a novel protein sequence‐conditioned molecule generation model, that combines contrastive protein‐molecule representation learning and latent optimization in a shared pretrained space, enabling de novo, target‐specific design from sequence alone.
Can Koban, Gökçe Uludoğan, Elif Ozkirimli, Arzucan Özgür   +3 more
wiley   +1 more source

Evaluating benefit-to-burden ratios of the established and emerging colorectal cancer screening strategies. [PDF]

J Natl Cancer Inst
Ebner DW, Fendrick AM, Kisiel JB, Estes C, Vahdat V, Ozbay AB, Limburg PJ.   +6 more
europepmc   +1 more source

Structural Features of Highly Bioactive Citrus IntegroPectin Revealed by X‐Ray Diffraction, Fourier Transform Infrared, and Nanoparticle Tracking Analysis

ChemistryOpen, Volume 15, Issue 5, May 2026.
Structural investigation of lemon, orange, and red orange IntegroPectin using X‐ray diffraction, infrared spectroscopy, and nanoparticle tracking analysis unveils several structural nuances of relevance to forthcoming studies on the use of citrus IntegroPectin for therapy and prevention of numerous diseases.
Rosaria Ciriminna, Ana Rosa Garcia, Giuseppe Angellotti, Giovanna Li Petri, Chiara Valenza, Francesco Mauriello, Domenico Nuzzo, Pasquale Picone, Antonella Girgenti, Caterina Di Sano, Claudia D’Anna, Mario Pagliaro   +11 more
wiley   +1 more source