Results 161 to 170 of about 34,376 (260)

Computational Identification of Potent Multitarget Natural Ligands for Alzheimer's Disease Therapeutics. [PDF]

Scientifica (Cairo)
Sharif N, Bibi A, Sadiq R, Ullah I, Rauf A, Arshad MT, Bashir S, Zamir H, Gull S, Anwar T, Laryea E.   +10 more
europepmc   +1 more source

From “Passive Supplementation” to “Active Repair”: Melatonin Reshapes the Treatment Paradigm for Late‐Onset Hypogonadism by Targeting Leydig Cell Senescence

Aging Cell, Volume 25, Issue 5, May 2026.
Melatonin restores testosterone production in aging Leydig cells by targeting key pathological drivers, particularly oxidative stress and mitochondrial dysfunction. This approach offers a fundamental strategy to reshape the Late‐onset hypogonadism treatment paradigm.
Hui Wu, Gang Ning, Mintao Jian, Ajian Peng, Haoyu Wang, Bonan Li, Xing Zhou   +6 more
wiley   +1 more source

Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling

Journal of Diabetes Investigation, Volume 17, Issue 5, Page 751-765, May 2026.
Molecular mechanism of synergistic antagonism of ANGPTL4 and VEGF by ginsenoside Rg3 combined with ranibizumab, regulating the NRP/RhoA pathway to inhibit macular edema. ABSTRACT Aims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ...
Jiexin Yu, Xingyu Li, Yanli Liu
wiley   +1 more source

Baicalin protects against heat-induced multiorgan dysfunction <i>via</i> organ-specific protein modulation: integrative <i>in silico</i> and <i>in vivo</i> evidence. [PDF]

RSC Adv
Kumari A, Tufail A, Abdellattif MH, Dubey A, Sinha RK.   +4 more
europepmc   +1 more source

Salvia miltiorrhiza‐Derived Vesicle‐Like Nanoparticles Functionalised Hydrogel With Excellent Ability of Oxidative Stress Modulation and Anti‐Cardiomyocyte Apoptosis for Sepsis‐Induced Myocardial Injury

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3391-3406, May 2026.
ABSTRACT In the process of myocardial cell structural and functional damage caused by various factors, current therapeutic strategies primarily focus on restoring myocardial blood supply, often neglecting the inherent complex microenvironment triggered by elevated reactive oxygen species (ROS) levels during myocardial injury.
Zhichao Liu, Shixiang Chen, Baomin Dou, Zhen Shen, Hao Liu, Xizhen Wang, Liyue Zhu, Yue Qiu, Zhongxi Lyu, Te Ba, Kuicheng Li, Jinhong Chen, Ningcen Li   +12 more
wiley   +1 more source

Repurposing Product Nkabinde for Hepatitis B Virus Therapy: A Network Pharmacology and Molecular Docking Investigation. [PDF]

Pharmaceuticals (Basel)
Ugbaja SC, Nkabinde SA, Nkabinde M, Gqaleni N.   +3 more
europepmc   +1 more source

Early Experimental Report of the First 8‐Gene‐Edited Pig‐to‐Rhesus Macaque Cardiac Xenotransplantation in China

Xenotransplantation, Volume 33, Issue 3, May/June 2026.
ABSTRACT Objectives This study aimed to investigate the functional recovery of an 8‐gene‐edited pig heart after orthotopic xenotransplantation, the characteristics of the recipient's immune responses, and the efficacy of postoperative complication management to provide comprehensive experimental evidence for the clinical translation of xenogeneic ...
Xianzhi Wang, Xijie Wu, Ziqiang Dai, Licheng Yan, Jie Yan, Dongsheng He, Shangxuan Li, Zhipeng Ren, Gen Zhang, Guanzheng Cui, Xin Li, Xianhua Li, Yulong Guan, Guangyu Pan, Ik Jin Yun, Wensheng Zhou, Dengke Pan, Dianyuan Li   +17 more
wiley   +1 more source

Successful Management of Relapsing Primary Focal Segmental Glomerulosclerosis With Tacrolimus and Mycophenolate Multitarget Therapy. [PDF]

Case Rep Nephrol
Lee F, Yeam A, Quizon MR, Lau WL.
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Breast cancer is the most frequently diagnosed malignancy and a leading cause of cancer‐related mortality among women worldwide. Triple‐negative breast cancer (TNBC) poses a major clinical challenge due to its aggressive nature, limited therapeutic options, and high propensity for drug resistance.
Lara Luzietti, Gustavo Salgado Pires, Ana Ryan, Crisamie Regidor, Matthew Hiller, Danilo Sarti, Tríona Ní Chonghaile, Pedro de Sena Murteira Pinheiro, Damir Varešlija, Daniel Alencar Rodrigues   +9 more
wiley   +1 more source

Quantitative Mapping of Nanoscale EGFR–Grb2 Assemblies by DNA‐PAINT

ChemPhysChem, Volume 27, Issue 8, 28 April 2026.
Single‐molecule DNA‐PAINT imaging resolves the nanoscale organization of epidermal growth factor receptor (EGFR) and the adaptor protein Grb2 in cells. An analysis workflow quantitatively reports EGF‐induced EGFR reorganization, increased oligomerization, and progressive Grb2 recruitment at individual membrane‐protein assembly sites.Receptor tyrosine ...
Alexandra Kaminer, Yunqing Li, Hans‐Dieter Barth, Marina S. Dietz, Mike Heilemann   +4 more
wiley   +1 more source