Results 71 to 80 of about 602,867 (155)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Multitarget Tracking by Particle Filtering Based on RSS Measurement in Wireless Sensor Networks

International Journal of Distributed Sensor Networks, 2015
We propose an algorithm for multitarget tracking by particle filtering in wireless sensor networks based on received signal strength (RSS) measurement where we also localize a newly appearing target whose location and reference power are unknown ...
Jaechan Lim, Uipil Chong
doaj   +1 more source

Exact Closed-Form Multitarget Bayes Filters

Sensors, 2019
The finite-set statistics (FISST) foundational approach to multitarget tracking and information fusion has inspired work by dozens of research groups in at least 20 nations; and FISST publications have been cited tens of thousands of times.
Ronald Mahler
doaj   +1 more source

DiaActive protocol: A randomized controlled trial of cognitive‐motor multicomponent exercise to reduce fall rate in older adults with diabetes

Diabetic Medicine, EarlyView.
Abstract Introduction Older adults with diabetes have an increased risk of falls due to neuropathy, impaired bone health and cardiovascular disease, resulting in significant morbidity and mortality. Conventional fall‐prevention programmes primarily target strength and balance, while cognitive‐motor integration, essential for safe mobility in complex ...
Aksayan Arunanthy Mahalingasivam, Asger Ahlmann Bech, Peter Vestergaard, Martin Grønbech Jørgensen, Nicklas Højgaard‐Hessellund Rasmussen   +4 more
wiley   +1 more source

Improved Multitarget Tracking in Clutter Using Bearings-Only Measurements

Sensors, 2018
Multitarget tracking in clutter using bearings-only measurements is a challenging problem. In this paper, a performance improved nonlinear filter is proposed on the basis of the Random Finite Set (RFS) theory and is named as Gaussian mixture measurements-
Yifang Shi, Mengfan Xue, Yuemin Ding, Dongliang Peng   +3 more
doaj   +1 more source

Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation

iNew Medicine, Volume 2, Issue 3, September 2026.
The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng, Wenhui Zhao, Min Wang, Xianwen Wang   +3 more
wiley   +1 more source

Synthesis, Anticancer Evaluation, mRNA Expression Analysis, and Molecular Docking of Fluorinated Picolinamide–Benzothiazole Derivatives Against Breast Cancer‐Related Genes CDK2, ERK2, and BCL2

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract summarizes the synthesis of novel benzothiazole‐linked derivatives and their biological evaluation. The compounds exhibited significant antioxidant activity, notable cytotoxic effects against MDA‐MB‐231 cells, apoptosis induction with G2/M arrest, gene regulation, and favorable molecular docking interactions, supporting their ...
Nagalakshmamma Vadabingi, Venkataswamy Mallepogu, Surendra Pothuraju, Chiranjeevi Pasala, Sumithra Poreddy, Uma Maheswari Amineni, Suresh Reddy Cirandur, Balaji Meriga   +7 more
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Box-particle intensity filter [PDF]

, 2012
This paper develops a novel approach for multi-target tracking, called box-particle intensity filter (box-iFilter). The approach is able to cope with unknown clutter, false alarms and estimates the unknown number of targets. Furthermore, it is capable of
Gning, Amadou, Streit, Roy, Mihaylova, Lyudmila, Cremers, Daniel, Koch, Wofgang, Schikora, Marek   +5 more
core   +1 more source