Results 41 to 50 of about 1,068,731 (282)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A demofobia na democracia moderna

open access: yesDados: Revista de Ciências Sociais, 2011
Dans cet article, on cherche à montrer l'existence de principes de démophobie dans la théorie de la démocratie moderne. On observe que des propositions théoriques libérales ont tranché sur le fait de subsumer le demos dans le gouvernement de tous, la ...
Thais Florencio de Aguiar
doaj   +1 more source

Agency Fact Sheet, Department of Iowa Workforce Development, FY2007 [PDF]

open access: yes, 2007
This document produced by the Iowa Department of Administrative Services has been developed to provide a multitude of information about executive branch agencies/department on a single sheet of paper.

core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Teologi Lokal dalam Konteks Global

open access: yesGema Teologika, 2016
Today in the globalization process the poor is marginalized. This reflection is based on the Indonesian context of economic dependence and marginalization of the poor and the powerless.
Johanes Baptista Giyana Banawiratma
doaj   +1 more source

Agency Fact Sheet, Department of Commerce: Utilities Board, FY2009 [PDF]

open access: yes, 2009
This document produced by the Iowa Department of Administrative Services has been developed to provide a multitude of information about executive branch agencies/department on a single sheet of paper.

core  

The Multitude of Unresolved Continuum Sources at 1.6 microns in Hubble Space Telescope images of Seyfert Galaxies [PDF]

open access: yes, 1999
We examine 112 Seyfert galaxies observed by the Hubble Space Telescope (HST) at 1.6 microns. We find that ~50% of the Seyfert 2.0 galaxies which are part of the Revised Shapeley-Ames (RSA) Catalog or the CfA redshift sample contain unresolved continuum ...
A. Alonso‐Herrero   +18 more
core   +5 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Beyond the Public and the Private : Thomas Spence and the Current Debate on Common Property

open access: yesMiranda: Revue Pluridisciplinaire du Monde Anglophone, 2016
The purpose of this article is to show the concept of common property of Thomas Spence (1750-1814) as a genealogy of the current political debate about the commons. This debate is characterized by two main ways of conceiving of common property : one that
Matilde Cazzola
doaj   +1 more source

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