Harnessing IgM for solid tumor therapy: biology, engineering advances, and translational challenges. [PDF]
Wang Y +8 more
europepmc +1 more source
In this work, the Doubao large language model (LLM) is involved in the formula derivation processes for Hubbard U determination regarding the second‐order perturbations of the chemical potential. The core ML tool is optimized for physical domain knowledge, which is not limited to parameter prediction but rather serves as an interactive physical theory ...
Mingzi Sun +8 more
wiley +1 more source
Modular Assembly of Dynamic Polymer Networks From Heteroaffinity Cross‐Links to Multivalent Proteins
This study develops a method to modularly assemble oligomeric binding proteins, like streptavidin, using heterobifunctional cross‐linkers that have both a strong‐ and a weak‐affinity binding moiety. These dynamic cross‐linkers enable the assembly of polymer networks with unique meta‐stable nonequilibrium topologies, and that exhibit chemically tunable ...
Tianyue Dai +6 more
wiley +2 more sources
Rational design of click-assembled chiral dendrimers: anticancer activity and molecular dynamics study. [PDF]
El Malah T, El-Rashedy AA.
europepmc +1 more source
Physicochemical and Mechanical Characterization of Commercial Collagen‐Based Wound Dressings
Commercial collagen‐based wound dressings are systematically compared to reveal how porous architecture governs hydration‐driven swelling and mechanical adaptation. Distinct structure–function relationships are identified, showing that wet‐state elasticity and conformability emerge from material composition and processing rather than manufacturer ...
Davide V. Verdolino +4 more
wiley +1 more source
Visualizing and Quantifying microRNA‐Induced DNA Origami Separation at the Nanoscale
Clinically relevant miRNA biomarkers trigger the disassembly of DNA origami dimers into monomers through a toehold‐mediated strand displacement reaction. High‐speed AFM was used to visualize this reaction in real time, while solid‐state nanopore measurements quantified the populations of dimers and monomers, as well as the resulting miRNA concentration,
Chalmers C. C. Chau +4 more
wiley +2 more sources
Molecular Additives as Competitive Binding Agents to Control Supramolecular-Driven Nanoparticle Assembly. [PDF]
Li RL, Sbalbi N, Ye M, Macfarlane RJ.
europepmc +1 more source
Detection of low‐abundance proteins at the point‐of‐care is key for early detection and real‐time monitoring. The clinical translation of such assays is hindered by biofouling, matrix variability, and signal instability. RT‐MagMAp assay overcomes these challenges and enables precise protein quantification in human plasma using a hierarchical assembly ...
Payel Sen +8 more
wiley +2 more sources
Editorial: Retroconstruction of porous crystalline networks for a sustainable future. [PDF]
Li X.
europepmc +1 more source
Monosaccharide Binding to Synthetic Carbohydrate Receptor Microarrays. [PDF]
Shlain MA +9 more
europepmc +1 more source

