Results 41 to 50 of about 9,030 (299)
Beilstein Journal of Organic Chemistry, 2020 Bisimidazolium receptors, tagged with chromophoric pyrene at one end and linked to an n-alkyl chain at the other, underwent self-assembly in aqueous media depending on the length of the alkyl segment.
Rakesh Biswas +3 more
doaj +1 more source
Molecules, 2021 Synthesis of tetravalent thio- and selenogalactopyranoside-containing glycoclusters using azide-alkyne click strategy is presented. Prepared compounds are potential ligands of Pseudomonas aeruginosa lectin PA-IL. P.
Tünde Zita Illyés +8 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 The first immobilization of a MacMillan’s first generation organocatalyst onto dendritic support is described. A modified tyrosine-based imidazolidin-4-one was grafted to a soluble high-loading hyperbranched polyglycerol via a copper-catalyzed alkyne ...
Tommaso Pecchioli +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Selective Integrin α5β1 Targeting through Spatially Constrained Multivalent DNA-Based Nanoparticles
Molecules, 2022 Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing ...
Eva E. Kurisinkal +4 more
doaj +1 more source
Multivalent glycosystems for nanoscience [PDF]
Beilstein Journal of Organic Chemistry, 2014 Carbohydrates constitute the most abundant class of biomolecules on Earth. They are “global players” and indeed play many roles. They store energy and water. They serve as metabolic intermediates. They function as stable, raw materials or as intelligent, bioengineered products. They are even active in “social media”, that is, they mediate communication
openaire +3 more sources
Sensing of Lead Ions by a Carboxylate-Substituted PPE: Multivalency Effects
, 2016 Sensing of Lead Ions by a Carboxylate-Substituted PPE: Multivalency ...
Uwe H. F. Bunz (1393282) +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Multivalency and cooperativity in supramolecular chemistry
, 2005 Multivalent interactions, which rely upon noncovalent bonds, are essential ingredients in the mediation of biological processes, as well as in the construction of complex (super)structures for materials applications.
Badjić, Jovica D. +4 more
core +1 more source