Results 31 to 40 of about 9,030 (299)
Multivalency in a Dendritic Host–Guest System [PDF]
, 2019 \u3cp\u3eMultivalency is an important instrument in the supramolecular chemistry toolkit for the creation of strong specific interactions. In this paper we investigate the multivalency effect in a dendritic host-guest system using molecular dynamics ...
Koen Pieterse +11 more
core +1 more source
Multivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications
Molecules, 2016 Nucleic acid aptamers generated through an in vitro selection are currently extensively applied as very valuable biomolecular tools thanks to their prominent advantages. Diversity of spatial structures, ease of production through chemical synthesis and a
Mariya Vorobyeva +2 more
doaj +1 more source
Faraday Discussions, 2019 In this introductory lecture we discuss the state-of-the-art glycan microarray technology, with emphasis on novel approaches to immobilize collections of glycans in a defined, multivalent manner.
Marco Mende +5 more
openaire +4 more sources
Correction: Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly [PDF]
, 2023 Correction for ‘Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly’ by Amrita Sikder et al., Mater. Horiz., 2023, 10, 171–178,
O’Reilly, Rachel; id_orcid +7 more
core +1 more source
Size Dependence of Steric Shielding and Multivalency Effects for Globular Binding Inhibitors [PDF]
, 2015 Competitive binding inhibitors based on multivalent nanoparticles have shown great potential for preventing virus infections. However, general design principles of highly efficient inhibitors are lacking as the quantitative impact of factors such as ...
Jonathan Vonnemann (1385409) +16 more
core +1 more source
, 2019 The last decade has witnessed a series of discoveries that question the traditional paradigm of multivalency as a >safe> strategy to enhance the binding affinity of a lectin receptor to its cognate carbohydrate ligand.
Ortiz-Mellet, Carmen +2 more
core +2 more sources
Clicked and long spaced galactosyl- and lactosylcalix[4]arenes: new multivalent galectin-3 ligands
Beilstein Journal of Organic Chemistry, 2014 Four novel calix[4]arene-based glycoclusters were synthesized by conjugating the saccharide units to the macrocyclic scaffold using the CuAAC reaction and using long and hydrophilic ethylene glycol spacers.
Silvia Bernardi +6 more
doaj +1 more source
Influence of length and flexibility of spacers on the binding affinity of divalent ligands
Beilstein Journal of Organic Chemistry, 2015 We present a quantitative model for the binding of divalent ligand–receptor systems. We study the influence of length and flexibility of the spacers on the overall binding affinity and derive general rules for the optimal ligand design.
Susanne Liese, Roland R. Netz
doaj +1 more source
Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores
Beilstein Journal of Organic Chemistry, 2014 Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and ...
Mathieu L. Lepage +6 more
doaj +1 more source
Multivalent scaffolds induce galectin-3 aggregation into nanoparticles
Beilstein Journal of Organic Chemistry, 2014 Galectin-3 meditates cell surface glycoprotein clustering, cross linking, and lattice formation. In cancer biology, galectin-3 has been reported to play a role in aggregation processes that lead to tumor embolization and survival.
Candace K. Goodman +5 more
doaj +1 more source