Results 21 to 30 of about 9,030 (299)

Multivalency in supramolecular chemistry and nanofabrication [PDF]

, 2004
Multivalency is a powerful and versatile self-assembly pathway that confers unique thermodynamic and kinetic behavior onto supramolecular complexes. The diversity of the examples of supramolecular multivalent systems discussed in this perspective shows ...
Reinhoudt, David, Mulder, A., Huskens, Jurriaan; id_orcid   +2 more
core   +1 more source

Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers

Molecules, 2018
Alzheimer’s disease is one of the most common chronic neurodegenerative disorders. Despite several in vivo and clinical studies, the cause of the disease is poorly understood. Currently, amyloid β (Aβ) peptide and its tendency to assemble
Éva Bartus, Gábor Olajos, Ildikó Schuster, Zsolt Bozsó, Mária A. Deli, Szilvia Veszelka, Fruzsina R. Walter, Zsolt Datki, Zsolt Szakonyi, Tamás A. Martinek, Livia Fülöp   +10 more
doaj   +1 more source

Nanoparticle‐Based Formulations of Glycopeptide Antibiotics: A Means for Overcoming Vancomycin Resistance in Bacterial Pathogens?

Advanced NanoBiomed Research, 2023
The occurrence and spreading of multidrug resistance in bacterial pathogens represent one of the greatest challenges of the 21st century. With fewer and fewer new antibiotics in development, novel and unconventional concepts in drug development and ...
Bhanu Kiran Pothineni, Adrian Keller
doaj   +1 more source

The Synthesis and Evaluation of Multivalent Glycopeptoids as Inhibitors of the Adhesion of Candida albicans

Pathogens, 2021
Multivalency is a strategy commonly used by medicinal carbohydrate chemists to increase the affinity of carbohydrate-based small molecules for their protein targets.
Harlei Martin, Hannah Masterson, Kevin Kavanagh, Trinidad Velasco-Torrijos   +3 more
doaj   +1 more source

The role of multivalency in the association kinetics of patchy particle complexes [PDF]

, 2017
Association and dissociation of particles are elementary steps in many natural and technological relevant processes. For many such processes, the presence of multiple binding sites is essential. For instance, protein complexes and regular structures such
Peter G. Bolhuis, Newton, Arthur C., Bolhuis, Peter G., Bolhuis, P.G., Kegel, Willem K., Newton, A.C., Kegel, W.K., Jan Groenewold, Arthur C. Newton, Willem K. Kegel, Groenewold, J., Groenewold, Jan, Physical and Colloid Chemistry, Sub Physical and Colloid Chemistry   +13 more
core   +3 more sources

Synthesis of multivalent carbohydrate mimetics with aminopolyol end groups and their evaluation as L-selectin inhibitors

Beilstein Journal of Organic Chemistry, 2015
In this article a series of divalent and trivalent carbohydrate mimetics on the basis of an enantiopure aminopyran and of serinol is described. These aminopolyols are connected by amide bonds to carboxylic acid derived spacer units either by Schotten ...
Joana Salta, Jens Dernedde, Hans-Ulrich Reissig   +2 more
doaj   +1 more source

Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers

Molecular Therapy: Nucleic Acids, 2020
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks expression of the three most common receptors present on other subtypes, leaving it unsusceptible to current targeted or hormonal therapies.
Danielle M. Valcourt, Emily S. Day
doaj   +1 more source

Factors That Govern the Induction of Long-Lived Antibody Responses

Viruses, 2020
The induction of long-lasting, high-titer antibody responses is critical to the efficacy of many vaccines. The ability to produce durable antibody responses is governed by the generation of the terminally differentiated antibody-secreting B cells known ...
Bryce Chackerian, David S. Peabody
doaj   +1 more source

The Symmetry of Viral Sialic Acid Binding Sites–Implications for Antiviral Strategies

Viruses, 2019
Virus infections are initiated by the attachment of the viral particle to protein or carbohydrate receptors on the host cell. Sialic acid-bearing glycan structures are prominently displayed at the cell surface, and, consequently, these structures can ...
Nils H. Rustmeier, Michael Strebl, Thilo Stehle   +2 more
doaj   +1 more source

Hybrid Multivalent Jack Bean α-Mannosidase Inhibitors: The First Example of Gold Nanoparticles Decorated with Deoxynojirimycin Inhitopes

Molecules, 2021
Among carbohydrate-processing enzymes, Jack bean α-mannosidase (JBα-man) is the glycosidase with the best responsiveness to the multivalent presentation of iminosugar inhitopes.
Costanza Vanni, Anne Bodlenner, Marco Marradi, Jérémy P. Schneider, Maria de los Angeles Ramirez, Sergio Moya, Andrea Goti, Francesca Cardona, Philippe Compain, Camilla Matassini   +9 more
doaj   +1 more source