Results 241 to 250 of about 739,378 (304)

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Context-Dependent Associations of PROGINS Variants with Progesterone Receptor Signaling and Biological Features in Diffuse Gliomas. [PDF]

Cancers (Basel)
Başkurt O, Kurnaz Gömleksiz Ö, Coşkun E, Ünlüer C, Aksakal MN, Raihanatou Kadijatou B, Özden M, Bozkurt M.   +7 more
europepmc   +1 more source

Revealing the Nanoscale Morphology Changes of Polymer Electrolyte Membrane Fuel Cell Catalyst Layers due to Conditioning

Advanced Science, EarlyView.
We apply ex situ and in situ scanning transmission X‐ray microscopy to reveal the structural degradation of polymer electrolyte membrane fuel cell catalyst layers due to conditioning and thermal heating of the catalyst coated membrane. We observe a redistribution of the ionomer and carbon‐black in the catalyst layer, as well as nanoscale membrane ...
Spencer Lytle, Harsharaj B. Parmar, Jian Wang, Shohei Yamashita, Aimy Bazylak   +4 more
wiley   +1 more source

Anthropometric, functional and lifestyle-related factors associated with testosterone levels among middle-aged men in Uzbekistan: protocol for a population-based cross-sectional study. [PDF]

BMJ Open
Abdurakhimov A, Azizova FL.
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Morphologic and urodynamic predictors of renal scarring in pediatric neurogenic bladder A cross-sectional study. [PDF]

Can Urol Assoc J
Yayla D, Aydın Z.
europepmc   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

Dietary, Lifestyle, and Psychological Factors Associated with Premenstrual Syndrome Among Female University Students in Saudi Arabia: A Cross-Sectional Study. [PDF]

Int J Womens Health
Huwaikem M.
europepmc   +1 more source

Tissue‐Agnostic Cellular Morphometric Biomarkers for Risk‐Adapted Management Across Gastrointestinal Precancerous Lesions and Cancers

Advanced Science, EarlyView.
An interpretable, unsupervised artificial intelligence framework identifies a 13‐cellular morphometric biomarker (CMB) signature from routine H&E whole‐slide images. Validated across 2,602 patients, the fixed signature generalizes across colorectal, gastric, and esophageal tissues without retraining, stratifies prognosis and precancerous lesion risk ...
Pin Wang, Chengfei Jiang, April W. Mao, Qi Sun, Yijun Lu, Jingjing Wei, Jamie L. Inman, Susan E. Celniker, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Bo Hang, Hang Chang, Lei Wang, Jian‐Hua Mao   +14 more
wiley   +1 more source

Feasibility and Safety Profile of Non-anesthesiologist-administered Propofol During Colorectal Endoscopic Submucosal Dissection: A Single-center Study of 454 Procedures. [PDF]

DEN Open
Kishi Y, Tanabe M, Uragami N, Shiomi D, Fukuda M, Kurahashi M, Hanzawa T, Yamaguchi M, Muraoka M, Nakamura H, Miyake R, Okada Y, Toyoda Y, Toshimori A, Ito T, Yokoyama N, Inoue H.   +16 more
europepmc   +1 more source