Results 91 to 100 of about 480,840 (327)

RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis

open access: yesAdvanced Science, EarlyView.
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao   +28 more
wiley   +1 more source

El creciente malestar de las Cortes Castellanas ante la invasión de la vida municipal por la nobleza (1433-1435)

open access: yesEspacio, Tiempo y Forma. Serie III, Historia Medieval, 2014
Solo una mínima parte del gran proyecto de reforma institucional diseñado en las Cortes de Zamora se aplica efectivamente, lo que explica el malestar que ponen de manifiesto las protestas de las cortes de Madrid de 1433; por otra parte, las Ordenanzas ...
Vicente Ángel Álvarez Palenzuela
doaj   +1 more source

The New State Preemption, The Future of Home Rule, and The Illinois Experience [PDF]

open access: yes, 2019
This article examines the rise of new forms of state preemption of local government legal authority in states across the nation, a trend that is prompting scholars, advocates, and officials to re-examine the underlying nature of home rule.
Davidson, Nestor M., Reynolds, Laurie
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

open access: yesAdvanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong   +6 more
wiley   +1 more source

Municipal panel data analysis for solid waste, local governments and citizen participation [PDF]

open access: yesGlobal Journal of Environmental Science and Management
BACKGROUND AND OBJECTIVES: Solid waste management in Ecuador is the responsibility of the municipal autonomous decentralised governments and is structured in a value chain from waste collection to final disposal.
P. Hernández Medina   +1 more
doaj   +1 more source

Local Land Use: Decision Expands Federal Government\u27s Role [PDF]

open access: yes, 2003
The United States Environmental Protection Agency (EPA), pursuant to its authority under the Clean Water Act, has promulgated regulations creating the Storm Water Management Program.
Nolon, John R.
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

open access: yesAdvanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang   +16 more
wiley   +1 more source

Summary Report for Round 1 of the Community Technical Assistance Program [PDF]

open access: yes, 2008
The New Hampshire Estuaries Project (NHEP) initiated its Community Technical Assistance Program (CTAP) in 2005. The program provides consulting assistance to the 42 New Hampshire communities that are part of the watershed areas for the Great Bay estuary,
Hunter, Jennifer
core   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

open access: yesAdvanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li   +9 more
wiley   +1 more source

Empowering local governments to make a disaster resilient built environment within Sri Lankan Cities [PDF]

open access: yes, 2013
Urban areas are growing very rapidly all over the world, particularly in developing countries. As a result of rapid urbanisation, the world’s population is increasingly concentrated in large cities leading to unplanned urban development with ...
Amaratunga, Dilanthi   +2 more
core  

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