Results 131 to 140 of about 1,803 (266)

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

open access: yesAdvanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen   +8 more
wiley   +1 more source

Fe/N‐Doped Carbon with Nearly Ordered Mesopores and Tunable Particle Sizes as Model Catalysts for Quantitative Evaluation of Electrocatalytic Active Sites

open access: yesAdvanced Science, EarlyView.
This study is dedicated to the design and synthesis of MOF‐derived mesoporous Fe/N‐doped carbons as model catalysts, aiming to quantitatively evaluate the utilization of active sites in the ORR. Through modulation followed by pyrolysis, we successfully prepare size‐tunable Fe/MNC‐x with doped iron atoms and mesoporous structures. The smaller Fe/MNC‐250
Hongjuan Zhang   +7 more
wiley   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang   +9 more
wiley   +1 more source

Addressing Oxygen Embrittlement in Additively Manufactured Titanium via Cu‐Mediated Interstitial Site Engineering

open access: yesAdvanced Science, EarlyView.
A novel “Cu‐mediated interstitial site engineering” strategy is introduced to thermodynamically stabilize hexagonal oxygen (hex‐O) configurations in oxygen‐containing titanium alloys. The hex‐O configuration activates multiple slip systems and enhances dislocation pinning via long‐range repulsion.
Xiaobin Lin   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy