Results 151 to 160 of about 1,668 (284)

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

Some considerations on the legal regulation of the process for public licitation, contracts and agreements on the establishment of educational partnerships between the government and the private sector

Educação: Teoria e Prática, 2009
Currently the joint between the public administration and the private sector assumes new contours in function of the of the Brazilian State reform, configuring itself as a trend that if it has accented in the educational area, in the São Paulo’s cities ...
Adriana A. Dragone Silveira
doaj  

Climate policy conflict in the U.S. states: a critical review and way forward. [PDF]

Clim Change, 2022
Basseches JA, Bromley-Trujillo R, Boykoff MT, Culhane T, Hall G, Healy N, Hess DJ, Hsu D, Krause RM, Prechel H, Roberts JT, Stephens JC.   +11 more
europepmc   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

The Family Health Strategy as a policy of the State: trajectory, institutional capacity and the current primary health care agenda. [PDF]

Cad Saude Publica
Klitzke D.
europepmc   +1 more source

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis

Advanced Science, EarlyView.
This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu, Jing Liu, Wenqian Zhou, Yangyang Niu, Yan Zheng, Yiguo Liu, Yingying Zhang, Chen Yu   +7 more
wiley   +1 more source

After the Open Dialogue: a Within-Area Comparison of Treatment, Experiences, and Outcomes in Western Lapland 20 Years after Service Fragmentation. [PDF]

Community Ment Health J
Bergström T, Miettunen J, Partanen K, Yrjänheikki V, Rantamaa K, Hietasaari T, Öfverberg E, Gauffin T, Petäjäniemi J.   +8 more
europepmc   +1 more source

Persistence of Schistosomiasis-Related Morbidity in Northeast Brazil: An Integrated Spatio-Temporal Analysis. [PDF]

Trop Med Infect Dis, 2021
Silva BMD, Ferreira AF, da Silva JAM, de Amorim RG, Domingues ALC, Pinheiro MCC, de Moraes Bezerra FS, Heukelbach J, Ramos AN.   +8 more
europepmc   +1 more source

Multi‐Stimuli Responsive Magneto‐Coacervate Droplets for Selective Molecular Enrichment and Programmable Manipulation

Advanced Science, EarlyView.
ABSTRACT Coacervate droplets formed via liquid–liquid phase separation offer unique opportunities as microreactors and delivery vehicles due to their ability to selectively concentrate biomolecules and support biochemical reactions. However, their passive nature severely restricts precise spatial and temporal control, posing barriers to practical ...
Kailang Liu, Haocheng Ran, Haohui Ou, Peiying Chen, Cheng Qi, Tiantian Kong, Zhou Liu   +6 more
wiley   +1 more source

HIV/AIDS in the state of Amazonas, Brazilian Amazon: decentralization, third-party support and community action. [PDF]

Rev Soc Bras Med Trop
Benzaken AS, Salimo ZM, Farias MEL, Omena AG, Hallal RC, Humar RCH, Jesus B, Safe IP, Lacerda MVG.   +8 more
europepmc   +1 more source