Results 201 to 210 of about 3,361 (294)
HIV/AIDS activism and the Unified Health System in Belém, Brazil, 1990-2003. [PDF]
Hist Cienc Saude ManguinhosSantos PHSD, Paiva CHA.
europepmc +1 more source
Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription
Advanced Science, EarlyView.This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen +14 more
wiley +1 more source
Advanced Science, EarlyView.Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi +8 more
wiley +1 more source
Endemic Disease Control Agents' perception on the fight against Aedes aegypti and the prevention of arbovirus infections in Brazil. [PDF]
PLoS Negl Trop Dis, 2019 Donateli CP +4 more
europepmc +1 more source
Local adaptation policy responses to extreme weather events. [PDF]
Policy Sci, 2020 Giordono L, Boudet H, Gard-Murray A.
europepmc +1 more source
Does municipalization affect the local unemployment rate? [PDF]
, 2014 Pascarella, Harry
core +2 more sources
Advanced Science, EarlyView.Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang +10 more
wiley +1 more source
The governors of school markets? Local education authorities, school choice and equity in Finland and Sweden. [PDF]
Res Comp Int Educ, 2018 Varjo J, Lundström U, Kalalahti M.
europepmc +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source